552291-22-2Relevant academic research and scientific papers
Identification of 1-arylmethyl-3-(2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists
Zhu, Yun-Fei,Gross, Timothy D.,Guo, Zhiqiang,Connors Jr., Patrick J.,Gao, Yinghong,Tucci, Fabio C.,Struthers, R. Scott,Reinhart, Greg J.,Saunders, John,Chen, Ta Kung,Killam Bonneville, Anne L.,Chen, Chen
, p. 2023 - 2026 (2007/10/03)
Based on SAR from bicyclic GnRH antagonists such as 6-aminomethyl-7-arylpyrrolo[1,2-a]pyrimid-4-ones (1) and 2-aryl-3-aminomethylimidazolo[1,2-a]pyrimid-5-ones (2a,b), a series of novel uracil compounds (4) were derived as the GnRH antagonists. Their synt
