552317-80-3Relevant academic research and scientific papers
Imidazopyrimidines, potent inhibitors of p38 MAP kinase
Rupert, Kenneth C.,Henry, James R.,Dodd, John H.,Wadsworth, Scott A.,Cavender, Druie E.,Olini, Gilbert C.,Fahmy, Bohumila,Siekierka, John J.
, p. 347 - 350 (2003)
The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-α and IL-1β. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-α in vivo.
