552318-07-7Relevant academic research and scientific papers
Tro?ger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study
Valík, Martin,Malina, Jaroslav,Palivec, Luká?,Foltynová, Jarmila,Tkadlecová, Marcela,Urbanová, Marie,Brabec, Viktor,Král, Vladimír
, p. 8591 - 8600 (2006)
'Head-to-head' oligo-N-methylpyrrole peptide dimers linked by a methano[1,5]diazocin scaffold are presented in racemic as well as chiral fashion. Their DNA binding activities were assayed on calf thymus DNA, poly(dA-dT)2, and poly(dC-dG)2
Selective formation of either Tr?ger's base or spiro Tr?ger's base derivatives from [2-aminoporphyrinato(2-)]nickel by choice of reaction conditions
Tatar, Ameneh,Dolensky, Bohumil,Dvo?áková, Hana,Král, Vladimír
supporting information, p. 6015 - 6017 (2013/01/13)
The article reports on the unique manipulation of the acid-catalyzed reaction of [2-aminoporphyrinato(2-)]nickel with formaldehyde to form selectively either the symmetric Tr?ger's base or the asymmetric spiro Tr?ger's base bis(metalloporphyrin) derivativ
Novel heterocyclic Tro?ger's base derivatives containing N-methylpyrrole units
Valík, Martin,Dolensky, Bohumil,Pet?í?ková, Hana,Va?ek, Petr,Král, Vladimír
, p. 2083 - 2086 (2007/10/03)
Novel analogues of Tr?ger's base were prepared regioselectively from 4-amino-N-methylpyrrole carboxylates in good yield. Catalytic hydrogenation of dibenzyl-4,9-methano-1,6-dimethyl-4,5,9,10-tetrahydro-1H,6H-dipyrrolo- [3,2-b:3′,2′-f][1,5]diazocin-2,7-dicarboxylate 2b led to 4,9-methano-1,6-dimethyl-4,5,9,10-tetrahydro-1H,6H-dipyrrolo-[3,2-b: 3′,2′-f][1,5]diazocin-2,7-dicarboxylic acid 3 which was used for the preparation of Tr?ger's base derivatives of natural antibiotics via an amide protocol. The novel heterocyclic Tr?ger's bases were characterized by a variety of spectroscopic techniques and compound 2b by X-ray crystallography. Incorporation of guanidine as the terminal group in the N-methylpyrrole Tr?ger's base skeleton opens the possibility for preparation of water soluble derivatives.
