552325-16-3

Basic information

• Product Name: A-443654
• Synonyms: A-443654;1H-Indole-3-ethanaMine, a-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]Methyl]-, (aS)-;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-(S)-1H-indole-3-ethanamine
• CAS NO: 552325-16-3
• Molecular Formula: C24H23N5O
• Molecular Weight: 397.47232
• Product Categories: Akt;mTOR;PI3K
• Mol File: 552325-16-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 722℃
• Flash Point: 390℃
• Appearance: /
• Density: 1.307
• Solubility: insoluble in H2O; ≥19.85 mg/mL in DMSO; ≥44.3 mg/mL in EtOH
• PKA: 13.43±0.40(Predicted)
• CAS DataBase Reference: A-443654(CAS DataBase Reference)
• NIST Chemistry Reference: A-443654(552325-16-3)
• EPA Substance Registry System: A-443654(552325-16-3)

Safety Data

• Hazardous Substances Data: 552325-16-3(Hazardous Substances Data)

Usage

General Description

A-443654 is a chemical compound that belongs to the class of pyrrolopyridines and has been characterized as a selective inhibitor of the phosphoinositide 3-kinase (PI3K) family of enzymes. It has been shown to have potential therapeutic applications in the treatment of cancer, inflammation, and autoimmune diseases due to its ability to inhibit the signaling pathways involved in these conditions. A-443654 has been studied for its anti-tumor effects in various cancer cell lines and has shown promising results in preclinical studies. Additionally, it has been investigated for its potential to alleviate symptoms of inflammatory diseases by targeting the PI3K pathway. A-443654 has garnered interest in the scientific community for its potential as a therapeutic agent and continues to be the subject of ongoing research.