552331-39-2

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 636-98-6 p-nitrobenzene iodide 
• 852510-25-9 3-(3-chloro-phenyl)-5-iodo-benzo[c]isoxazole 

Downstream Products

• 852510-26-0 (3-chloro-phenyl)-(5-iodo-2-methylamino-phenyl)-methanone 
• 852510-32-8 acetic acid {3-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-ylmethyl]-3H-imidazol-4-yl}-(4-cyano-phenyl)-methyl ester 
• 607715-99-1 4-(5-{[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-hydroxy-methyl}-imidazol-1-ylmethyl)-benzonitrile 
• 852510-43-1 4-(3-chloro-phenyl)-6-(5-hydroxymethyl-imidazol-1-ylmethyl)-1-methyl-1H-quinolin-2-one 
• 852510-45-3 6-(5-chloromethyl-imidazol-1-ylmethyl)-4-(3-chloro-phenyl)-1-methyl-1H-quinolin-2-one 
• 852510-27-1 4-(3-chloro-phenyl)-6-iodo-1-methyl-1H-quinolin-2-one 
• 852510-30-6 6-bromomethyl-4-(3-chloro-phenyl)-1-methyl-1H-quinolin-2-one 
• 852510-29-3 4-(3-chloro-phenyl)-6-hydroxymethyl-1-methyl-1H-quinolin-2-one 

Relevant academic research and scientific papers

Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors

Beginning with the structure of tipifarnib (1), a series of inhibitors of FTase have been synthesized by transposition of the D-ring to the imidazole and subsequent modification of the 2-quinolone motif. The compounds in the new series may be achiral and have structural features that allow for analogs that are difficult or impossible to make in the tertiary carbon-based tipifarnib series. The most potent compound (4d) is 4 times more active in vitro against FTase than tipifarnib.