552331-73-4

Basic information

• Product Name: 3-Bromo-5-(4-methoxybenzyloxy)pyridine
• Synonyms: 3-Bromo-5-(4-methoxybenzyloxy)pyridine;3-broMo-5-[(4-Methoxyphenyl)Methoxy]pyridine
• CAS NO: 552331-73-4
• Molecular Formula: C₁₃H₁₂BrNO₂
• Molecular Weight: 294.14
• EINECS: 604-604-1
• Product Categories: blocks;Bromides;Pyridines
• Mol File: 552331-73-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 383.232°C at 760 mmHg
• Flash Point: 185.573°C
• Appearance: /
• Density: 1.417g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: 2-8°C
• PKA: 2.10±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-5-(4-methoxybenzyloxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-(4-methoxybenzyloxy)pyridine(552331-73-4)
• EPA Substance Registry System: 3-Bromo-5-(4-methoxybenzyloxy)pyridine(552331-73-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 552331-73-4(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-(4-methoxybenzyloxy)pyridine is a chemical compound that belongs to the class of organic compounds known as aryl bromides. Its molecular formula is C13H12BrNO2. This chemical has a strong presence of N-benzylpyridinium, a substructure that characterizes it. It features a benzene ring, a pyridine ring, a bromine atom, a methoxy group, and a benzyloxy group. It is used as an intermediate for the synthesis of more complex compounds, often in pharmaceutical and chemical research. Its detailed properties such as its stability, reactivity, and potential hazards are typically determined via lab testing and spectroscopic analysis. As with all chemicals, it should be handled with appropriate safety measures.

InChI:InChI=1/C13H12BrNO2/c1-16-12-4-2-10(3-5-12)9-17-13-6-11(14)7-15-8-13/h2-8H,9H2,1H3

Upstream product

• 74115-13-2 5-bromopyridine-3-ol 
• 824-94-2 p-methoxybenzyl chloride 
• 625-92-3 3,5-dibromopyridine 
• 53942-86-2 4-methoxybenzyl alcohol sodium salt 

Downstream Products

• 552331-81-4 5-(4-methoxy-benzyloxy)-2-pyridin-4-yl-[1,7]naphthyridine 
• 552331-77-8 [4-formyl-5-(4-methoxy-benzyloxy)-pyridin-3-yl]-carbamic acid tert-butyl ester 
• 552331-75-6 [5-(4-methoxy-benzyloxy)-pyridin-3-yl]-carbamic acid tert-butyl ester 
• 552331-78-9 5-(4-methoxy-benzyloxy)-1H-[1,7]naphthyridin-2-one 
• 552331-80-3 2-chloro-5-(4-methoxy-benzyloxy)-[1,7]naphthyridine 
• 552331-74-5 3-amino-5-(4-methoxy-benzyloxy)-pyridine 
• 74115-13-2 5-bromopyridine-3-ol 

Relevant articles and documents

Pharmaceutical compounds

Compounds of Formulae Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

A comparison of the binding of three series of nicotinic ligands

A total of 24 aryl-substituted analogues of nicotine (1a) and two related series of nicotinic ligands, aminomethylpyridines 3 and ether analogues 8, were examined to determine if they bind at α4β2 nACh receptors in a common manner. A modest correlation (r=0.785) was found between the affinities of the nicotine analogues and derivatives of 3, but little correlation (r=0.348) was found with analogues 8. However, a modest correlation (r=0.742) exists between the binding of analogues 3 and 8. It seems that 1-series and 8-series compounds bind differently but that the 3-series compounds share some intermediate binding similarity with both.