552332-08-8

Basic information

• Product Name: 5-[5-((2S)-2-tert-Butoxycarbonylamino-3-phenyl-propoxy)-2-chloro-pyridin-3-yl]-3-methyl-indazole-1-carboxylic Acid Tert-Butyl Ester
• Synonyms: 5-[5-((2S)-2-tert-Butoxycarbonylamino-3-phenyl-propoxy)-2-chloro-pyridin-3-yl]-3-methyl-indazole-1-carboxylic Acid Tert-Butyl Ester
• CAS NO: 552332-08-8
• Molecular Weight: 593.123
• Mol File: 552332-08-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-[5-((2S)-2-tert-Butoxycarbonylamino-3-phenyl-propoxy)-2-chloro-pyridin-3-yl]-3-methyl-indazole-1-carboxylic Acid Tert-Butyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[5-((2S)-2-tert-Butoxycarbonylamino-3-phenyl-propoxy)-2-chloro-pyridin-3-yl]-3-methyl-indazole-1-carboxylic Acid Tert-Butyl Ester(552332-08-8)
• EPA Substance Registry System: 5-[5-((2S)-2-tert-Butoxycarbonylamino-3-phenyl-propoxy)-2-chloro-pyridin-3-yl]-3-methyl-indazole-1-carboxylic Acid Tert-Butyl Ester(552332-08-8)

Safety Data

• Hazardous Substances Data: 552332-08-8(Hazardous Substances Data)

Upstream product

• 864770-82-1 1,1-dimethylethyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate 
• 352704-97-3 5-[(S)-2-N-BOC-amino-3-phenyl-1-propyloxy]-2-chloro-3-bromo pyridine 

Downstream Products

• 864771-01-7 {(S)-1-benzyl-2-[6-benzyl-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethyl}-carbamic acid benzyl ester 
• 864772-32-7 [(1S)-2-{[5-(3-methyl-1H-indazol-5-yl)-6-(1-methyl-1H-pyrrol-2-yl)-3-pyridinyl]oxy}-1-(phenylmethyl)ethyl]amine 

Relevant articles and documents

2,3,5-Trisubstituted pyridines as selective AKT inhibitors-Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity

2,3,5-Trisubstituted pyridines have been designed as potent AKT inhibitors that are selective against ROCK1 based on the comparison between AKT and ROCK1 structures. Substitution at the 2-position of the core pyridine is the key element to provide selectivity against ROCK1. An X-ray co-crystal structure of 9p in PKA supports the proposed rationale of ROCK1 selectivity.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.