55243-15-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Ethyl 2-amino-2-(2-pyridinyl)acetate is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the creation of a wide range of compounds with diverse biological activities, making it a valuable component in drug discovery and development.
Used in Coordination Chemistry:
Ethyl 2-amino-2-(2-pyridinyl)acetate is used as a ligand in coordination chemistry. Its ability to form stable complexes with metal ions makes it a useful component in the design and synthesis of metal-organic frameworks and other coordination compounds with potential applications in catalysis, sensing, and materials science.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
Ethyl 2-amino-2-(2-pyridinyl)acetate is used as a chiral auxiliary in asymmetric synthesis. Its chiral center and unique structural features enable the selective formation of enantiomerically pure compounds, which is crucial in the synthesis of biologically active molecules and pharmaceuticals.
Used in Medicinal Chemistry for Neuroprotection and Anticonvulsant Properties:
Ethyl 2-amino-2-(2-pyridinyl)acetate has been studied for its potential anticonvulsant and neuroprotective properties. Its ability to modulate neuronal activity and protect against neurodegeneration makes it a promising candidate for the development of new therapeutic agents for the treatment of epilepsy and other neurological disorders.

Upstream product

• 71721-67-0 ethyl 2-hydroxyimino-2-(pyridin-2-yl)acetate 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 

Downstream Products

• 119448-87-2 ethyl imidazo[1,5-a]pyridine-1-carboxylate 
• 1430074-74-0 ethyl 3-phenylimidazo[1,5-α]pyridine-1-carboxylate 
• 1430074-80-8 ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,5-α]pyridine-1-carboxylate 
• 1430074-84-2 ethyl 3-(4-methoxyphenyl)imidazo[1,5-α]pyridine-1-carboxylate 
• 924646-16-2 3-phenylimidazo[1,5-a]pyridine-1-carboxylic acid 
• 1451194-92-5 C₁₅H₉F₃N₂O₂ 
• 1018557-23-7 C₁₅H₁₂N₂O₃ 
• 1451194-91-4 C₂₃H₂₆N₄O₃ 
• 1451194-90-3 C₂₄H₂₅F₃N₄O₃ 
• 1451194-89-0 C₂₄H₂₈N₄O₄ 
• 1380811-20-0 C₁₈H₁₈N₄O 
• 1380811-30-2 C₁₉H₁₇F₃N₄O 
• 1380811-29-9 C₁₉H₂₀N₄O₂ 
• 1380810-42-3 C₃₈H₄₆N₆O₆S₂ 

Relevant academic research and scientific papers

Synthesis and biological evaluation of imidazopyridinyl-1,3,4-oxadiazole conjugates as apoptosis inducers and topoisomerase IIα inhibitors

A series of imidazopyridinyl-1,3,4-oxadiazole conjugates were synthesized and investigated for their cytotoxic activity and some compounds showed promising cytotoxic activity. Compound 8q (NSC: 763639) exhibited notable growth inhibition that satisfies th

THERAPEUTIC INHIBITORY COMPOUNDS

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Synthesis and SAR of Imidazo[1,5-a[pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disease which has a higher prevalence and incidence in older people. The need for improved AD therapies is unmet. The 5-hydroxytryptamine4 receptor (5-HT4R) partial agonists may be of benefit for both the symptomatic and disease-modifying treatment of cognitive disorders associated with AD. Herein, we report the design, synthesis and SAR of imidazo[1,5-a] pyridine derivatives as 5-HT4R partial agonists. The focused SAR, optimization of ADME properties resulted the discovery of compound 5a as potent, selective, brain penetrant 5-HT4 partial agonist as a lead compound with good ADME properties and efficacy in both symptomatic and disease modifying animal models of cognition.

Design, synthesis and biological evaluation of imidazo[1,5-a]pyridine-PBD conjugates as potential DNA-directed alkylating agents

A series of novel imidazo[1,5-a]pyridine-PBD conjugates were synthesized and evaluated for their antitumor activity in breast cancer cell line (MCF-7). Interestingly, all the compounds showed enhanced DNA binding ability. These conjugates showed significa

Acidic triazoles as soluble guanylate cyclase stimulators

A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF3 triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25.

CGRP RECEPTOR ANTAGONISTS

Compounds of Formula I: (where variables R1, R2, R3, R7, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache, and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.