55247-60-4Relevant academic research and scientific papers
Squalene synthase inhibitors: Isosteric replacements of the farnesyl chain of benzyl farnesyl amine
Brinkman, John A.,Damon, Robert E.,Fell, Jay B.,Perez, Lawerence B.,Scallen, Terence J.,Vedananda
, p. 2491 - 2494 (2007/10/03)
Squalene synthase catalyzes the committed step of cholesterol biosynthesis. We report here the synthesis and in vivo activity of a series of squalene synthase inhibitors that contain isosteric replacements for the farnesyl chain of the known inhibitor ben
