55253-30-0Relevant academic research and scientific papers
Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists
Witt, Jonathan O.,McCollum, Andrea L.,Hurtado, Miguel A.,Huseman, Eric D.,Jeffries, Daniel E.,Temple, Kayla J.,Plumley, Hyekyung C.,Blobaum, Anna L.,Lindsley, Craig W.,Hopkins, Corey R.
, p. 2481 - 2488 (2016)
Herein, we report the synthesis and structure-activity relationship of a series of chiral alkoxymethyl morpholine analogs. Our efforts have culminated in the identification of (S)-2-(((6-chloropyridin-2-yl)oxy)methyl)-4-((6-fluoro-1H-indol-3-yl)methyl)morpholine as a novel potent and selective dopamine D4 receptor antagonist with selectivity against the other dopamine receptors tested (1, D2L, D2S, D3, and D5).
