55258-76-9

Usage

Uses

Used in Pharmaceutical Industry:
4-Ethyl-2-fluoro-1,1'-biphenyl is used as a photoproduct for [application type] in the development and study of anti-inflammatory drugs. [application reason] As a result of its association with Flurbiprofen, 4-ETHYL-2-FLUORO-1,1'-BIPHENYL may have potential applications in understanding the photochemical behavior of anti-inflammatory medications, which could lead to the development of more effective and safer drugs for pain relief and inflammation management.
Used in Research and Development:
4-Ethyl-2-fluoro-1,1'-biphenyl is used as a research compound for [application type] in the field of medicinal chemistry and pharmacology. [application reason] Its unique structure and properties make it a valuable tool for studying the effects of structural modifications on the biological activity of anti-inflammatory drugs, potentially contributing to the discovery of novel therapeutic agents with improved efficacy and reduced side effects.

Upstream product

• 63444-55-3 4-ethenyl-2-fluorobiphenyl 
• 5104-49-4 fluorobiprofen 

Downstream Products

• 5104-49-4 fluorobiprofen 

Relevant academic research and scientific papers

Photo-Mediated Decarboxylative Giese-Type Reaction Using Organic Pyrimidopteridine Photoredox Catalysts

The decarboxylative Giese-type reaction offers a versatile methodology for the radical alkylation of electron-deficient alkenes. Photo-mediated variants often require a pre-activation of carboxylic acids and/or employment of costly transition-metal photocatalysts. Herein, we present a metal-free photocatalyzed decarboxylative Giese-type addition to electron-deficient alkenes using pyrimidopteridine N-oxides as organic photoredox-active catalysts. This protocol comprises mono-, di-, and trisubstituted aliphatic, α-amino, and α-oxy acids as well as a variety of electron-deficient alkenes. Moreover, post-synthetic derivatization and applications are presented.

Photocarboxylation of Benzylic C-H Bonds

The carboxylation of sp3-hybridized C-H bonds with CO2 is a challenging transformation. Herein, we report a visible-light-mediated carboxylation of benzylic C-H bonds with CO2 into 2-arylpropionic acids under metal-free conditions. Photo-oxidized triisopropylsilanethiol was used as the hydrogen atom transfer catalyst to afford a benzylic radical that accepts an electron from the reduced form of 2,3,4,6-tetra(9H-carbazol-9-yl)-5-(1-phenylethyl)benzonitrile generated in situ. The resulting benzylic carbanion reacts with CO2 to generate the corresponding carboxylic acid after protonation. The reaction proceeded without the addition of any sacrificial electron donor, electron acceptor or stoichiometric additives. Moderate to good yields of the desired products were obtained in a broad substrate scope. Several drugs were successfully synthesized using the novel strategy.

Selective Cobalt-Catalyzed Reduction of Terminal Alkenes and Alkynes Using (EtO)2Si(Me)H as a Stoichiometric Reductant

While attempting to effect Co-catalyzed hydrosilylation of β-vinyl trimethylsilyl enol ethers, we discovered that, depending on the silane, solvent, and the method of generation of the reduced cobalt catalyst, a highly efficient and selective reduction or hydrosilylation of an alkene can be achieved. This paper deals with this reduction reaction, which has not been reported before in spite of the huge research activity in this area. The reaction, which uses the air-stable [2,6-bis(aryliminoyl)pyridine)]CoCl2 activated by 2 equiv of NaEt3BH as the catalyst (0.001-0.05 equiv) and (EtO)2SiMeH as the hydrogen source, is best run at ambient temperature in toluene and is highly selective for the reduction of simple unsubstituted 1-alkenes and the terminal double bonds in 1,3- and 1,4-dienes, β-vinyl ketones, and silyloxy dienes. The reaction is tolerant of various functional groups such as bromide, alcohol, amine, carbonyl, di- or trisubstituted double bonds, and water. Highly selective reduction of a terminal alkyne to either an alkene or alkane can be accomplished by using stoichiometric amounts of the silane. Preliminary mechanistic studies indicate that the reaction is stoichiometric in the silane and both hydrogens in the product come from the silane.

Process for producing biphenyl derivatives

A process for producing a halobiphenyl derivative represented by the following formula (I) comprises dehydrogenating a cyclohexylhalobenzene represented by the following formula (II) under such conditions that substantially no dehalogenation occurs. STR1 wherein X represents a halogen atom, and each of R1 and R2 independently represents a group represented by the formula STR2 wherein A represents carboxyl or an alkoxycarbonyl group and R represents a hydrogen atom or a lower alkyl group; an alkylcarbonyl; alkenyl; alkynyl; alkyl; aryl; arylcarbonyl; hydroxyalkyl; cyanoalkyl or cyanoalkenyl group.

Anti-inflammatory composition and method containing 2-fluoro-4-isopropylbiphenyl

Novel substituted aromatic hydrocarbons and ethers, and pharmaceutical compositions containing them, are described. They have pharmaceutical activity, e.g. as anti-inflammatory agents.