55260-28-1

Basic information

• Product Name: 1-[2,4,6-Tris-(tetrahydro-pyran-2-yloxy)-phenyl]-ethanone
• Synonyms: 1-[2,4,6-Tris-(tetrahydro-pyran-2-yloxy)-phenyl]-ethanone
• CAS NO: 55260-28-1
• Molecular Weight: 420.503
• Mol File: 55260-28-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[2,4,6-Tris-(tetrahydro-pyran-2-yloxy)-phenyl]-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2,4,6-Tris-(tetrahydro-pyran-2-yloxy)-phenyl]-ethanone(55260-28-1)
• EPA Substance Registry System: 1-[2,4,6-Tris-(tetrahydro-pyran-2-yloxy)-phenyl]-ethanone(55260-28-1)

Safety Data

• Hazardous Substances Data: 55260-28-1(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 480-66-0 2,4,6-trihydroxyacetophenone 

Downstream Products

• 25515-46-2 naringenin chalcone 
• 14917-41-0 2',3,4,4',6'-pentahydroxychalcone 
• 82451-30-7 2',4',6'-trihydroxychalcone 

Relevant articles and documents

3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors

A novel series of 3,4-dihydroxychalcones was synthesized to evaluate their effects against 5-lipoxygenase and cyclooxygenase. Almost all compounds exhibited potent inhibitory effects on 5-lipoxygenase with antioxidative effects, and some also inhibited cyclooxygenase. The 2',5'-disubstituted 3,4- dihydroxychalcones with hydroxy or alkoxy groups exhibited optimal inhibition of cyclooxygenase. We found that 2',5'-dimethoxy-3,4-dihydroxychalcone (37; HX-0836) inhibited cyclooxygenase to the same degree as flufenamic acid and 5-lipoxygenase, more than quercetin. Finally, these active inhibitors of 5- lipoxygenase inhibited arachidonic acid-induced mouse ear edema more than phenidone.