55261-00-2

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-3-HYDROXYTETRAHYDROTHIOPHENE, 1,1-DIOXIDE is used as a key intermediate in the synthesis of various pharmaceuticals for its potential anti-inflammatory and antioxidant properties. It aids in the development of drugs targeting a range of health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-AMINO-3-HYDROXYTETRAHYDROTHIOPHENE, 1,1-DIOXIDE is utilized as a building block in the creation of agrochemicals, leveraging its antibacterial and antifungal activities to protect crops and enhance agricultural productivity.
Used in Research and Development:
4-AMINO-3-HYDROXYTETRAHYDROTHIOPHENE, 1,1-DIOXIDE is employed as a subject of study in research for its potential therapeutic applications, including the development of new drugs and treatments based on its unique chemical structure and properties.

InChI:InChI=1/C4H9NO3S/c5-3-1-9(7,8)2-4(3)6/h3-4,6H,1-2,5H2/t3-,4-/m0/s1

Upstream product

• 20688-38-4 rac-3-hydroxy-4-chlorotetrahydrothiophene-1,1-dioxide 
• 4509-11-9 3,4-epoxy-tetrahydro-thiophene-1,1-dioxide 

Downstream Products

• 118787-58-9 N-benzoyl-N'-(1,1-dioxo-3-hydroxythiolan-4-yl)thiourea 
• 86043-47-2 N-phenyl-N'-(4-hydroxy-1,1-dioxothiolan-3-yl)thiourea 
• 118787-55-6 1-Benzyl-3-((3R,4R)-4-hydroxy-1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl)-thiourea 
• 75135-29-4 trans-(3-Hydroxy-1,1-dioxothiolan-4-ylamino)acetic acid 
• 86043-48-3 N-(o-methoxyphenyl)-N'-(4-hydroxy-1,1-dioxothiolan-3-yl)thiourea 
• 156144-18-2 3-Benzamido-4-(benzoyloxy)tetrahydrothiophene 1,1-dioxide 
• 156144-22-8 4-Nitro-benzoic acid 4-(4-nitro-benzoylamino)-1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl ester 
• 98426-91-6 Acetic acid 4-acetylamino-1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl ester 

Relevant academic research and scientific papers

Kinase inhibitor compounds

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.

KINASE INHIBITOR COMPOUNDS

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.

Structure-activity studies of cyclic ketone inhibitors of the serine protease plasmin: Design, synthesis, and biological activity

Three series of cyclic ketone inhibitors were synthesized and evaluated against the serine protease plasmin. Peptide inhibitors that incorporated 3-oxotetrahydrofuran and 3-oxotetrahydrothiophene 1,1-dioxide groups had the highest activities. Alkylamino substituents, which were designed to bind in the S1 subsite of plasmin, were attached to the inhibitors. Compounds 5c and 5g, which incorporated 6-aminohexyl substituents, were found to be optimal and demonstrated IC50 values in the low micromolar range. Incorporating conformationally constrained peptide segments into the inhibitors did not improve their activities.