55266-18-7 Usage
Description
MnTBAP (55266-18-7) is a superoxide dismutase (SOD) mimetic. Potent peroxynitrite scavenger but does not scavenge nitric oxide.
Uses
MnTBAP chloride is a cell permeable superoxide dismutase mimetic and peroxynitrite scavenger.
General Description
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 μM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
Biochem/physiol Actions
Cell permeable: yes
References
1) Szabo et al. (1996), Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial resporation in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger; FEBS Lett., 381 82
2) Faulkner et al. (1994), Stable MN(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo; J. Biol. Chem., 269 23471
Check Digit Verification of cas no
The CAS Registry Mumber 55266-18-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,2,6 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 55266-18:
(7*5)+(6*5)+(5*2)+(4*6)+(3*6)+(2*1)+(1*8)=127
127 % 10 = 7
So 55266-18-7 is a valid CAS Registry Number.
