55275-75-7Relevant academic research and scientific papers
Synthesis of C15 and C10 fuel precursors with cyclopentanone and furfural derived from hemicellulose
Wang, Wei,Ji, Xiaohui,Ge, Hongguang,Li, Zhizhou,Tian, Guanghui,Shao, Xianzhao,Zhang, Qiang
, p. 16901 - 16907 (2017/03/24)
Fuel precursors 2,5-bis(2-furylmethylidene)cyclopentanone (F2Cp) and 2-(2-furylmethylidene)cyclopentanone (FCp) were obtained through aldol condensation of cyclopentanone and furfural over solid acid catalysts under solvent-free conditions. Nafion exhibited the best performance among the investigated catalysts (Nafion, Amberlyst-15, Amberlyst-36, H-USY, ZSM-5, H-β, and SiO2/Al2O3). Under optimized conditions, yields of F2Cp and FCp were 37.48% and 23.77%, respectively. Selectivities of F2Cp and FCp were 50.74% and 32.18%, respectively. Nafion showed good stability and did not deactivate during 4 runs. Meanwhile, a certain amount of humin was also generated during the reaction. The reaction mechanism for the aldol condensation of cyclopentanone and furfural and the formation mechanism of humin were also proposed.
Ultrasound mediation for efficient synthesis of monoarylidene derivatives of homo- and heterocyclic ketones
Mojtahedi, Mohammad M.,Abaee, M. Saeed,Samianifard, Mehdieh,Shamloo, Akram,Padyab, Masoomeh,Mesbah, A. Wahid,Harms, Klaus
, p. 924 - 930 (2013/03/13)
Ultrasonic irradiation was efficiently used for high yield synthesis of monoarylidene derivatives of cyclic systems directly from the reaction of ketone with various aldehydes under solvent-free conditions. Reactions took place rapidly in the presence of catalytic amounts of pyrrolidine, while no significant formation of the undesired bis by-products was observed. Moreover, the procedure was applicable to both homo- and heterocyclic ketones.
Facile synthesis and characterization of substituted pyrimidin-2(1H)-ones and their chalcone precursors
Ajani, Olayinka Oyewale,Ituen, Ruth Itoroabasi,Falomo, Ayorinde
experimental part, p. 59 - 67 (2012/06/01)
A new and efficient method has been developed for the quantitative transformation of chalcones to pyrimidine frame work vSa solid support catalysis, Silica supported sulphuric acid (SSA) efficiently catalyzed the reaction of α-β-unsaturated earbonyl, chalcones (140) with urea to afford substituted pyriniidin-2(1H)-ones (11-20) hi good to excellent yield. The interesting behaviour of SSA lies in the thct that it can be re-used after simple washing with chloroform thereby rendering this procedure more economical, The chemical structures were confirmed by analytical data as well as spectroscopic means.
Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists
Galambos, Janos,Wagner, Gabor,Nogradi, Katalin,Bielik, Attila,Molnar, Laszlo,Bobok, Amrita,Horvath, Attila,Kiss, Bela,Kolok, Sandor,Nagy, Jozsef,Kurko, Dalma,Bakk, Monika L.,Vastag, Monika,Saghy, Katalin,Gyertyan, Istvan,Gal, Krisztina,Greiner, Istvan,Szombathelyi, Zsolt,Keser, Gyoergy M.,Domany, Gyoergy
scheme or table, p. 4371 - 4375 (2010/10/02)
Hit-to-lead optimization of a HTS hit led to new carbamoyloxime derivatives. After identification of an advanced hit (8d) the CYP enzyme inhibitory activity of this class of compounds was successfully eliminated. Systematic exploration of different parts of the advanced hit led us to some promising lead compounds with mGluR5 affinities comparable to that of MPEP.
Quinoline synthesis: Scope and regiochemistry of photocyclisation of substituted benzylidenecyclopentanone O-alkyl and O-acetyloximes
Austin, Mark,Egan, Oliver J.,Tully, Raymond,Pratt, Albert C.
, p. 3778 - 3786 (2008/10/09)
Irradiation of substituted 2-benzylidenecyclopentanone O-alkyl and O-acetyloximes in methanol provides a convenient synthesis of alkyl, alkoxy, hydroxy, acetoxy, amino, dimethylamino and benzo substituted annulated quinolines. para-Substituents yield 6-substituted-2,3-dihydro-1H-cyclopenta[b] quinolines with 8-substituted products being obtained from ortho-substituted starting materials. Reactions of meta-substituted precursors are highly regioselective, with alkyl substituents leading to 5-substituted 2,3-dihydro-1H-cyclopenta[b]quinolines and more strongly electron-donating substituents generally resulting in 7-substituted products. 2-Furylmethylene and 2-thienylmethylene analogues yield annulated furo- and thieno-[2,3e]pyridines respectively. Sequential E- to Z-benzylidene group isomerisation and six π-electron cyclisation steps result in formation of a short-lived dihydroquinoline intermediate which spontaneously aromatises by elimination of an alcohol or acetic acid. For 2-benzylidenecyclopentanone O-allyloxime, singlet excited states are involved in both steps. The Royal Society of Chemistry 2007.
