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CAS

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552830-51-0

Resolvin E1 is an omega-3 polyunsaturated fatty acid derivative that possesses potent anti-inflammatory, pro-resolution, and anti-nociceptive properties. It plays a crucial role in modulating the inflammatory response and promoting tissue repair, making it a promising candidate for various therapeutic applications.

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  • 552830-51-0 Structure

  • Basic information

    1. Product Name: Resolvin E1
    2. Synonyms: Resolvin E1
    3. CAS NO:552830-51-0
    4. Molecular Formula: C20H30O5
    5. Molecular Weight: 350.4492
    6. EINECS: N/A
    7. Product Categories: Aliphatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 552830-51-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 591.3±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.112±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 4.66±0.10(Predicted)
    10. CAS DataBase Reference: Resolvin E1(CAS DataBase Reference)
    11. NIST Chemistry Reference: Resolvin E1(552830-51-0)
    12. EPA Substance Registry System: Resolvin E1(552830-51-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 552830-51-0(Hazardous Substances Data)

552830-51-0 Usage

Uses

Used in Pharmaceutical Applications:
Resolvin E1 is used as an anti-inflammatory agent for reducing inflammation and promoting tissue repair. Its potent anti-inflammatory effects make it a valuable candidate for the treatment of various inflammatory conditions.
Used in Pain Management:
Resolvin E1 is used as an analgesic for managing neuropathic pain and spinal cord microglial activation following peripheral nerve injury. Its anti-nociceptive properties help alleviate pain and improve the quality of life for patients suffering from nerve-related pain.
Used in Neurological Applications:
Resolvin E1 is used as a neuroprotective agent for promoting the resolution of neuroinflammation and supporting the recovery of nerve function. Its ability to inhibit neuropathic pain and spinal cord microglial activation makes it a potential therapeutic option for neurological disorders characterized by inflammation and nerve damage.

Check Digit Verification of cas no

The CAS Registry Mumber 552830-51-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,5,2,8,3 and 0 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 552830-51:
(8*5)+(7*5)+(6*2)+(5*8)+(4*3)+(3*0)+(2*5)+(1*1)=150
150 % 10 = 0
So 552830-51-0 is a valid CAS Registry Number.

552830-51-0Downstream Products

552830-51-0Relevant articles and documents

Synthesis of Resolvin E1 and Its Conformationally Restricted Cyclopropane Congeners with Potent Anti-Inflammatory Effect

Ishimura, Kohei,Fukuda, Hayato,Fujiwara, Koichi,Muromoto, Ryuta,Hirashima, Koki,Murakami, Yuto,Watanabe, Mizuki,Ishihara, Jun,Matsuda, Tadashi,Shuto, Satoshi

, p. 256 - 261 (2021)

RvE1 (1) is an endogenous lipid mediator with very potent anti-inflammatory activity, which is due to the inhibition of neutrophil chemotaxis and inflammatory cytokine production and the promotion of macrophage phagocytosis. On the basis of the conformational analysis of RvE1, we designed its four cyclopropane congeners (2a-d), in which the conformationally flexible terminal C1-C4 moiety of RvE1 was rigidified by introducing stereoisomeric cyclopropanes. The four congeners and also RvE1 were efficiently synthesized via a common synthetic route. The evaluation of the anti-inflammatory effects of the compounds in mice resulted in the identification of trans-β-CP-RvE1 (2d), which was significantly more active than RvE1, as a potential lead for anti-inflammatory drugs of a novel mechanism of action.

A Modular, Enantioselective Synthesis of Resolvins D3, E1, and Hybrids

Anderson, Edward A.,Elbert, bryony L.,Llaveria, Josep,Streatfeild, penelope E.,Urbitsch, Felix

, (2020/02/28)

Resolvins D3 and E1 are important signaling molecules in the resolution of inflammation. Here, we report a convergent and flexible strategy to prepare these natural products using Hiyama-Denmark coupling of five- and six-membered cyclic alkenylsiloxanes to connect three resolvin fragments, and control the stereochemistry of the natural product (Z)-alkenes. The modular nature of this approach enables the synthesis of novel resolvin hybrids, opening up opportunities for more-extensive investigations of resolvin biology.

COMPOSITIONS AND METHODS RELATING TO SALTS OF SPECIALIZED PRO-RESOLVING MEDIATORS OF INFLAMMATION

-

, (2018/01/17)

The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

Total synthesis of resolvin E1

Ogawa, Narihito,Kobayashi, Yuichi

scheme or table, p. 6079 - 6082 (2010/03/01)

Resolvin E1 (RvE1), which is an endogenous mediator to resolve inflammation, was synthesized by Wittig reaction between the C15-C20 aldehyde and the C10-C14 phosphonium salt possessing the vinyl iodo moiety followed by Suzuki-Miyaura coupling of the resul

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