552831-23-9

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 25333-42-0 (R)-quinuclidin-3-ol 

Downstream Products

• 1207274-75-6 carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester 
• 1207275-05-5 carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3-fluoro-phenyl)-(2-fluoro-phenyl)-methyl ester 
• 1172614-00-4 (S)-((R)-quinuclidin-3-yl) 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate hydrogensulfate 
• 180272-14-4 (S,R)-((R)-quinuclidin-3-yl) 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 740780-79-4 (3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate 
• 242478-37-1 solifenacin 
• 1262506-09-1 solifenacin succinate 
• 1416618-74-0 (R)-quinuclidin-3-yl phenethylcarbamate 
• 385367-47-5 Tarafenacin 

Relevant academic research and scientific papers

Process for the Preparation of Solifenacin and Salts Thereof

The invention provides a new process for the preparation of solifenacin or a pharmaceutically acceptable acid addition salt thereof, comprising reacting (R)-quinuclidin-3-yl phenethylcarbamate with benzaldehyde in the presence of an acid to obtain a diast

PROCESS FOR THE PREPARATION OF SOLIFENACIN AND SALTS THEREOF

The invention provides a new process for the preparation of solifenacin or a pharmaceutically acceptable acid addition salt thereof, comprising reacting (R)- quinuclidin-3-yl phenethylcarbamate with benzaldehyde in the presence of an acid to obtain a diasteroisomeric mixture (S,R)-((R)-quinuclidin-3-yl) 1 -phenyl-3,4- dihydroisoquinoline-2(1 H)-carboxylate of formula (IV) which can be resolved and the solifenacin or a pharmaceutically acceptable acid addition salt thereof recovered. The invention also provides the new key intermediate (R)-quinuclidin-3-yl phenethylcarbamate involved in the process. Further the invention provides a method for the transformation of (R)-((R)-quinuclidin-3-yl) 1 -phenyl-3,4- dihydroisoquinoline-2(1 H)-carboxylate into a diasteroisomeric mixture (S,R)-((R)- quinuclidin-3-yl) 1 -phenyl-3,4-dihydroisoquinoline-2(1 H)-carboxylate.

QUINUCLIDINE CARBONATE SALTS AND MEDICINAL COMPOSITION THEREOF

Quinuclidine carbonate derivatives act as muscarinic receptor antagonists and are effective for the prevention and/or treatment of a broncho-obstructive or inflammatory diseases.

Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester

The present invention refers to a stable crystalline salt of (R)-3-fluorophenyl- 3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo [2.2.2]oct-3-yl ester of formula (I) and its use as medicament, in particular for the treatment of urinary incontinence or oth