552840-04-7Relevant academic research and scientific papers
Enantioselective synthesis of α-substituted ketones by asymmetric addition of chiral zinc enamides to 1-alkenes
Nakamura, Masaharu,Hatakeyama, Takuji,Hara, Kenji,Nakamura, Eiichi
, p. 6362 - 6363 (2007/10/03)
A zinc enamide of a chiral imine derived from a ketone and (S)-valinol or (S)-t-leucinol undergoes addition to 1-alkene to generate a γ-zincioimine intermediate, which reacts with a carbon electrophile to give upon hydrolysis an optically active α-substituted ketone in good yield. The stereoselectivity of the addition reaction may reach 99% for the reaction of a cyclohexanone imine with ethylene. Copyright
