552847-32-2

Upstream product

• 6456-74-2 Glycine tert-butyl ester 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 27532-96-3 glycine tert-butyl ester hydrochloride 
• 38024-18-9 glycine tert-butyl ester, acetic acid salt 

Downstream Products

• 937204-24-5 C₂₄H₄₀N₂O₇SiS 
• 501097-16-1 [(3-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-propyl)-(2-nitro-benzenesulfonyl)-amino]-acetic acid tert-butyl ester 
• 501097-20-7 [{3-[(3-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-propyl)-(2-nitro-benzenesulfonyl)-amino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

WATER-SOLUBLE TRIAZAPYRIDINOPHANE-BASED COMPLEXING AGENTS AND CORRESPONDING FLUORESCENT LANTHANIDE COMPLEXES

The invention relates to complexing agents of formula (I) in which A1, A2, A3 and R1 are as defined in the description. The invention also relates to lanthanide complexes obtained from said complexing agents. The invention can be used for marking biological molecules.

New advances in the synthesis of tripyridinophane macrocycles suitable to enhance the luminescence of Ln(III) ions in aqueous solution

A series of four new 18-membered hexaaza macrocyclic ligands bearing three endocyclic pyridine units and acetate or methylenephosphonate pendant arms has been prepared. The new synthetic procedure is based on the use of amine and diamine precursors incorporating masked carboxylate or phosphonate functions and on an efficient sodium template effect which controls the crucial macrocyclization step (yields of macrocyclization reactions: 62–88%). This procedure appears as a suitable alternative compared to the classical Richman-Atkins methodology generally used for the preparation of this class of macrocycles. As demonstrated with the EuIII and TbIII complexes derived from two ligands, these tripyridinophane chelators form luminescent and stable mononuclear LnIII complexes in aqueous solution at physiological pH. In such a medium, TbIII complexes exhibit a brightness of 1700 (λexc = 279 nm) and 3000 (λexc = 268 nm) M?1 cm?1.

COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION

The present invention relates to the use of piperazinones for inhibiting arenavirus infection in humans, other mammals, or in cell culture, to methods of treating arenavirus infection such as Lassa, Bolivian, Argentine, Venezuelan, Brazilian, Chapare and

Stereocontrolled total synthesis of (-)-kainic acid

A stereocontrolled total synthesis of (-)-kainic acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the resultant

Modelling, synthesis and biological evaluation of an ethidium-arginine conjugate linked to a ribonuclease mimic directed against TAR RNA of HIV-1

Using molecular modelling studies, an active anti-HIV ethidium-arginine conjugate targeted against the viral TAR RNA sequence has been linked to an artificial ribonuclease, with the aim to obtain an irreversible inhibitor. The ribonuclease moiety consists of an N-[N-(3-aminopropyl)-3-aminopropyl] glycine and has been constructed via two successive N-alkylations following the Fukuyama procedure.