552867-99-9Relevant academic research and scientific papers
Quinolone-based IMPDH inhibitors: Introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues
Dhar, T. G. Murali,Watterson, Scott H.,Chen, Ping,Shen, Zhongqi,Gu, Henry H.,Norris, Derek,Carlsen, Marianne,Haslow, Kristin D.,Pitts, William J.,Guo, Junqing,Chorba, John,Fleener, Catherine A.,Rouleau, Katherine A.,Townsend, Robert,Hollenbaugh, Diane,Iwanowicz, Edwin J.
, p. 547 - 551 (2007/10/03)
The synthesis and the structure-activity relationships (SAR) of analogues derived from the introduction of basic residues on ring D of quinolone-based inhibitors of IMPDH are described. This led to the identification of compound 27 as a potent inhibitor of IMPDH with significantly improved aqueous solubility over the lead compound 1.
Heterocycles that are inhibitors of IMPDH enzyme
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, (2008/06/13)
Compounds of the formula 1wherein X1 is C(O), —S(O)—, or —S(O)2—; X2 is CR3 or N; X3 is —NH—, —O—, or —S—; X4 is CR4 or N; X5 is CR5 or N; and X6 is CR6 or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH-associated disorders.
