5530-36-9

Usage

Uses

Used in Organic Synthesis:
(2E)-1-(2,4-dinitrophenyl)-2-(2-phenylpropylidene)hydrazine is used as a reagent for the preparation of hydrazones and other derivatives, playing a crucial role in the development of new organic compounds.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (2E)-1-(2,4-dinitrophenyl)-2-(2-phenylpropylidene)hydrazine is used as a building block for the synthesis of biologically active compounds, contributing to the creation of potential new drugs and therapeutic agents.
It is important to handle this chemical with care, as it may pose potential health and safety hazards. Proper safety precautions should be taken when working with (2E)-1-(2,4-dinitrophenyl)-2-(2-phenylpropylidene)hydrazine to ensure the well-being of those involved in its synthesis and application.

Upstream product

• 34713-70-7 2-Phenylpropanal 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 

Relevant academic research and scientific papers

Hypoiodite-catalyzed regioselective oxidation of alkenes: An expeditious access to aldehydes in aqueous micellar media

A highly anti-Markovnikov selective oxidation of alkenes based on in situ generated hypoiodite catalysis in aqueous micellar media under mild conditions has been described. This novel catalytic system realizes an efficient synthesis of aldehydes from alkenes in an economically viable and environmentally safe fashion. The preliminary mechanistic studies suggest that the reaction proceeds via tandem iodofunctionalization/1,2-aryl or alkyl migration. The scope and limitations of this tandem process are demonstrated with various mono- and disubstituted (terminal and internal) olefins.

A modification of a conventional technique for the synthesis of hydrazones of racemic carbonyls: Prevention of spontaneous chiral inversion

Conventionally hydrazones and other derivatives of carbonyls are synthesized under acidic conditions when spontaneous chiral inversion is a common problem if the carbonyl compound is chiral. A new method has been developed involving solid phase microwave-assisted conditions for the synthesis of 2,4-dinitrophenyl hydrazone(s) of chiral carbonyl compounds wherein there occurred no inversion of configuration. The method provided high yields (91-95%) in short reaction times (4-6 min). The method proposed clearly has synthetic advantages over current practices. The hydrazones were characterized by IR, 1H NMR and CHN analysis. The hydrazones represent enantiomeric pairs tagged with a strong chromophore rather than diastereomers. The enantiomeric pairs were separated by HPLC using an α1-acid glycoprotein column and the best resolution of all the analytes was achieved with a mobile phase containing 0.5% 2-propanol in 10 mM citrate phosphate buffer at pH 6.5. The chromatographic peaks clearly showed base line separation with comparable peak areas and thus the results confirmed that there was no spontaneous inversion of configuration during derivatization. The chromatograms corresponding to the products obtained by conventional procedure (from the racemic mixtures of analytes) showed peaks with unequal areas suggesting formation of enantiomers in unequal amounts (i.e., non racemic mixtures) because of spontaneous inversion of the configuration during derivatization.