55304-09-1

Basic information

• Product Name: Benzene, 1-isocyanato-3-(1-methylethyl)- (9CI)
• Synonyms: Benzene, 1-isocyanato-3-(1-methylethyl)- (9CI)
• CAS NO: 55304-09-1
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.20044
• Product Categories: ISOPROPYL
• Mol File: 55304-09-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzene, 1-isocyanato-3-(1-methylethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-isocyanato-3-(1-methylethyl)- (9CI)(55304-09-1)
• EPA Substance Registry System: Benzene, 1-isocyanato-3-(1-methylethyl)- (9CI)(55304-09-1)

Safety Data

• Hazardous Substances Data: 55304-09-1(Hazardous Substances Data)

Upstream product

• 5369-16-4 meta-iso-propyl aniline 
• 530-62-1 1,1'-carbonyldiimidazole 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 1423126-70-8 C₂₁H₂₀N₆O₂ 
• 1423126-79-7 C₁₆H₁₈N₂O₂ 

Relevant articles and documents

COMPOUNDS, COMPOSITIONS, AND METHODS FOR SELECTIVELY INHIBITING β-GLUCURONIDASES AND ALLEVIATING SIDE EFFECTS ASSOCIATED WITH DRUG TREATMENT INDUCED DIARRHEA

The present disclosure describes compounds and compositions that inhibit β-glucuronidase activity, and methods for attenuating the side effects of one or more drugs and improving the efficacy of drugs by administration of selective β-glucuronidase inhibitors.

Discovery of novel anti-angiogenesis agents. Part 8: Diaryl thiourea bearing 1H-indazole-3-amine as multi-target RTKs inhibitors

VEGFR-2, TIE-2, and EphB4 are essential for both angiogenesis and tumorigenesis. Herein, we designed and prepared three classes of multi-target inhibitors based on the extensive sequence homology along the kinase domain of angiogenic RTKs. Biological evaluation indicated that these multi-target inhibitors exhibited considerable potential as novel anti-angiogeneic and anticancer agents. Among them, a diaryl thiourea bearing 1H-indazole-3-amine (16a) displayed the most potent RTK inhibition and excellent selectivity. It also showed inhibition on viability of human umbilical vein endothelial cells and anti-proliferation against a broad spectrum of cancer cells. Therefore, 1H-indazole-3-amine could serve as a promising hinge binding group for multi-target inhibitors of VEGFR-2, Tie-2, and EphB4.

CARBONIC ANHYDRASE INHIBITORS AND USES RELATED THERETO

In certain embodiments, this disclosure relates to carbonic anhydrase inhibitors that are phenylureidobenzenesulfonamide derivatives and uses related thereto. In certain embodiments, the phenylureidobenzenesulfonamide derivatives are of Formula I, wherein