55306-06-4

Upstream product

• 426219-75-2 dimethyl 8-oxo-13,14,15,16,17-pentanorlabd-6-ene-12,19-dioate 
• 426219-77-4 (1S,4aS,5R,8aR)-1,4a-Dimethyl-6-oxo-5-(2-oxo-ethyl)-decahydro-naphthalene-1-carboxylic acid 
• 55050-21-0 methyl 13,14,15,16-tetranorlabd-6-ene-12,8β-olide-19-oate 
• 81757-80-4 8-oxo-13,14,15,16,17-pentanorlabdane-12,19-dioic acid 
• 81800-51-3 dimethyl 8-oxo-13,14,15,16,17-pentanorlabdane-12,19-dioate 
• 1231-35-2 (E)-communic acid 

Relevant academic research and scientific papers

First synthesis of the antifungal oidiolactone C from trans-communic acid: Cytotoxic and antimicrobial activity in podolactone-related compounds

The synthesis of the fungicide oidiolactone C starting from diterpenic trans-communic acid was carried out with an overall yield of 11.7%. The key step in the process consists of a new bislactonization reaction catalyzed by Pd(II), which gives rise to the podolactone-type tetracyclic skeleton from a norlabdadienedioic acid. We also carried out a study of the structure-biological activity of different natural podolactones and their synthetic precursors. Thus, the highest cytotoxic activity was found in dienic dilactones with ether-type substitutions on C-17, whereas the closure of the γ-lactone ring is not critical for presenting a maximal antimicrobial activity.