5531-98-6

Usage

Uses

Used in Cardiovascular Disease Treatment:
Atherospermine is used as an anti-atherosclerotic agent for its ability to inhibit the production of inflammatory cytokines and reduce the adherence of white blood cells to endothelial cells, which can contribute to the development of atherosclerosis.
Used in Anti-Inflammatory Applications:
Atherospermine is used as an anti-inflammatory agent for its potential to mitigate inflammation, a key factor in the progression of various diseases.
Used in Cancer Treatment:
Atherospermine is used as an anti-tumor agent for its demonstrated potential anti-tumor activity, and it is being researched for its potential use in cancer treatment, offering a new avenue for therapeutic intervention in oncology.
Used in Pharmaceutical Research:
Atherospermine is used as a subject of pharmaceutical research for its multifaceted therapeutic potential, including the development of novel drug delivery systems to enhance its bioavailability and therapeutic outcomes in treating cardiovascular diseases and cancer.

InChI:InChI=1/C20H23NO2/c1-21(2)12-11-15-13-18(22-3)20(23-4)19-16-8-6-5-7-14(16)9-10-17(15)19/h5-10,13H,11-12H2,1-4H3

Upstream product

• 99272-81-8 N-carbethoxy-N-methyl-2-(3',4'-dimethoxy-1'-phenanthryl)ethylamine 
• 148370-32-5 1,2-dimethoxy-4,5,6a,7-tetrahydrodibenzo[de,g]chromen-5-one 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 109558-14-7 β-(3,4-dimethoxyphenyl)ethyl-(2'-bromophenyl)acetamide 
• 80041-81-2 1-(2-bromobenzyl)-3,4-dihydro-6,7-dimethoxyisoquinoline 
• 78946-19-7 1-(2'-bromobenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 839673-82-4 1-(2'-bromobenzyl)-N-tert-butyloxycarbonyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 5868-18-8 nuciferine 
• 754919-24-9 C₂₀H₂₄NO₂⁽¹⁺⁾ 
• 129958-80-1 N-carbethoxy-2-(3',4'-dimethoxy-1'-phenanthryl)ethylamine 
• 129958-76-5 2-(3,4-dimethoxy-1-phenanthryl)acetamide 
• 129958-78-7 2-(3',4'-dimethoxy-1'-phenanthryl)ethylamine 
• 475-83-2 R-(-)-nuciferine 
• 104385-30-0 (6S,6aR)-1,2-dimethoxy-6-methyl-6-oxo-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline 

Relevant academic research and scientific papers

3,4-Dihydroxy- and 3,4-methylenedioxy- phenanthrene-type alkaloids with high selectivity for D2 dopamine receptor

Dopamine-mediated neurotransmission plays an important role in relevant psychiatric and neurological disorders. Nowadays, there is an enormous interest in the development of new drugs acting at the dopamine receptors (DR) as potential new targets for the

A new convenient synthesis of phenanthrene alkaloids from 1-arylmethyl-1,2,3,4-tetrahydroisoquinolines

Hofmann degradation of 1-arylmethyl-1,2,3,4-tetrahydro-2,2- dimethylisoquinolinium iodides with methanolic KOH gave stilbene derivatives, for example, (E)-N-2{2-[2-(phenyl)ethenyl]-4,5-dimethoxyphenyl}ethyl-N,N- dimethylamine. Photochemical electrocycliza

Radical cyclization to dibenzo[de,g] chromanones. A new synthesis of phenanthrene compounds

We describe the radical cyclization of bromobenzylisochromanones to afford the novel dibenzo[de, g]chromanones. Opening the lactone ring of the latter allows the preparation of phenanthrene alkaloids and 1-phenanthrenylacetic acids.

TRANSFORMATION FROM APORPHINE N-OXIDES TO 1-(N-METHYL-N-HYDROXYLAMINOETHYL)PHENANTHRENE DERIVATIVES

Heat treatment of aporphine N-oxides prepared by the m-chloroperbenzoic acid (m-CPBA) oxidation of aporphines afforded 1-(N-methyl-N-hydroxylaminoethyl)phenanthrene derivatives which were characterized by the physical and chemical evidences.The biogenetic pathway from aporphines to phenanthrenes is also discussed.

Reductive Dicarbonyl Coupling with Low-valent Titanium Reagents: a New Entry to Phenanthrene Alkaloids

A new and direct synthesis of phenanthrene alkaloids using a low-valent titanium reagent is described which is compatible with ethoxycarbonyl as the N-protecting group.

Antibacterial and antifungal activity of liriodenine and related oxoaporphine alkaloids

Liriodenine was evaluated for its antibacterial and antifungal activity against several microorganisms. Other related oxoaporphine alkaloids also were evaluated. Attempts to prepare oxoaporphine alkaloids from N-acetylnoraporphines were unsuccessful, but an unexpected phenanthrene alkaloid was obtained. A novel N-demethylation reaction was noted when oxoglaucine methiodide and liriodenine methiodide were treated with alumina.