55327-54-3

Upstream product

• 106-47-8 4-chloro-aniline 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 143874-29-7 (3R,4S)-4-(4-Bromo-phenyl)-1-(4-chloro-phenyl)-3-phenyl-azetidin-2-one 
• 1122-91-4 4-bromo-benzaldehyde 
• 1602-00-2 bis-(4-chloro-phenyl)-diazene 
• 1000406-07-4 2-(4-bromophenyl)-1-(4-chlorophenyl)-3-(trifluoromethyl)-5-(thiophen-2-yl)-1H-pyrrole 
• 1000405-99-1 2-(4-bromophenyl)-1-(4-chlorophenyl)-3-(trifluoromethyl)-5-phenyl-1H-pyrrole 
• 1309440-28-5 benzyl 2-(ethoxycarbonyl)-1-(4-chlorophenylamino)-1-(4-bromophenyl)-3-phenylpropan-2-ylcarbamate 
• 312632-34-1 2-(4-bromophenyl)-3-(4-chlorophenyl)-2,3-dihydroquinazolin-4(1H)-one 

Relevant academic research and scientific papers

Investigations on growth and crystalline perfection of an organic Schiff base material: 4-Chloro-4′bromobenzylidene aniline

Single crystal of an organic material, 4-chloro-4′bromobenzylidene aniline (CBBA), was synthesized and grown by slow evaporation method at room temperature. 1H and 13C NMR spectra were recorded to elucidate the molecular structure an

Synthesis and characterization of tetrachloro-1,3-oxazepine derivatives and evaluation of their biological activities

6,7,8,9-Tetrachloro[1,3]oxazepine-1,5-dione derivatives 1b-10b have been synthesized by reacting Schiff bases 1a-10a with tetrachlorophthalic anhydride (TCPA) under (2 + 5 → 7) cycloaddition reaction conditons. All reactions had been monitored using TLC.

Cross-dehydrogenative coupling strategy for phosphonation and cyanation of secondary N-alkyl anilines by employing 2,3-dichloro-5,6-dicyanobenzoquinone

The cross-dehydrogenative coupling strategy for metal-free phosphonation and cyanation of secondary N-alkyl anilines has been developed firstly under mild reaction conditions. Based on detailed optimization of reaction conditions, the substrate generality of N-alkyl anilines and various hydrogen phosphonates has been investigated, and a series of versatile α-aminophosphonates and α-aminonitriles were therefore furnished in good to excellent yields. A plausible collective reaction mechanism through dehydrogenation to imine formation, then to respective α-aminophosphonates and α-aminonitriles was proposed.

Solvent-free synthesis of azomethines, spectral correlations and antimicrobial activities of some E-benzylidene-4-chlorobenzenamines

Some azomethines including substituted benzylidene-4-chlorobenzenamines (E-imines) have been synthesized by fly-ash: PTS catalyzed microwave assisted condensation of 4-chloroaniline and substituted benzaldehydes under solvent-free conditions. The yield of the imines has been found to be more than 85%. The purity of all imines has been checked using their physical constants and UV, IR and NMR spectral data. These spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The antimicrobial activities of all imines have been studied using standard methods.

Synthesis of N-benzyl-N-phenylthiophene-2-carboxamide analogues as a novel class of enterovirus 71 inhibitors

A series of novel human enterovirus 71 inhibitors, N-benzyl-N-phenylthiophene-2-carboxamide analogues, were synthesized and their antiviral activities were evaluated in vitro. Most derivatives of this structure against EV71 had a low micromolar range in the RD (rhabdomyosarcoma) cell lines. The most potent compound 5a, N-(4-bromobenzyl)-N-(4-fluorophenyl)thiophene-2-carboxamide, showed low micromolar activity against EV71 (EC50 = 1.42 μM) compared to the reference anti-EV71 drug enviroxime (EC50 = 0.15 μM). Preliminary SAR studies revealed that the thiophene-2-carboxamide core is crucial for maintaining antiviral activity, and N-substituent phenyl groups largely influenced the anti-EV71 efficacy of this new class of potent antiviral agents.

Investigations on growth and crystalline perfection of an organic Schiff base material: 4-Chloro-4′bromobenzylidene aniline

Single crystal of an organic material, 4-chloro-4′bromobenzylidene aniline (CBBA), was synthesized and grown by slow evaporation method at room temperature. 1H and 13C NMR spectra were recorded to elucidate the molecular structure an

GREEN SYNTHESIS OF ARYL ALDIMINES USING ETHYL LACTATE

The present invention relates to a method for preparing aryl aldimines. In particular, the present invention relates to methods of preparing aryl aldimines that uses environmentally friendly solvent systems.

MODIFICATION OF CRYSTAL PACKING AND MOLECULAR CONFORMATION VIA SYSTEMATIC SUBSTITUTION

Variations in molecular conformation and crystal packing are investigated by systematically altering the substituents on a molecule which has two degrees of conformational freedom.The crystal structures of the heterodisubstituted benzylideneanilines (BA's),p-chloro-N-(p-chlorobenzylidene) aniline (BrCl) and p-bromo-N-(p-chlorobenzylidene) aniline (ClBr) have been determined.The conformations of the two molecules are different from each other but are similar to those found in the crystal structures of the homodisubstituted derivatives with which they are isomorphous: p-bromo-N-(p-bromo-benzylidene) aniline (BrBr) and the orthorombic form of p-chloro-N-(p-chloro-benzylidene)aniline (ClCl) respectively.Because of this isomorphous relationship it is concluded that the substituent on the benzylidene ring plays a crucial role in determining the packing mode of the structure.

Polarographic investigations on azomethines: Benzal-p-chloranilines in alkaline medium and effect of substituents on half-wave potentials

Polarographic behavior of twenty-four substituted benzal-p-chloranilines has been investigated in 50percent methanol-water medium in alkaline pH range.The experimental conditions for the study were so designed that no appreciable hydrolysis of the Schiff