55329-22-1

Basic information

• Product Name: 4-CHLORO-6-METHYL-2-(METHYLSULFONYL)PYRIMIDINE
• Synonyms: 4-CHLORO-6-METHYL-2-(METHYLSULFONYL)PYRIMIDINE
• CAS NO: 55329-22-1
• Molecular Formula: C₆H₇ClN₂O₂S
• Molecular Weight: 206.65
• Mol File: 55329-22-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 244-245 °C
• Boiling Point: 384.488°C at 760 mmHg
• Flash Point: 186.332°C
• Appearance: /
• Density: 1.416
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.05±0.30(Predicted)
• CAS DataBase Reference: 4-CHLORO-6-METHYL-2-(METHYLSULFONYL)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-6-METHYL-2-(METHYLSULFONYL)PYRIMIDINE(55329-22-1)
• EPA Substance Registry System: 4-CHLORO-6-METHYL-2-(METHYLSULFONYL)PYRIMIDINE(55329-22-1)

Safety Data

• Hazardous Substances Data: 55329-22-1(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-methyl-2-(methylsulfonyl)pyrimidine is a chemical compound categorized under the class of organic compounds known as pyrimidines and pyrimidine derivatives. This chemical is characterized by a pyrimidine ring which is a six-membered heterocyclic ring structure analogous to benzene and pyridine, featuring two nitrogen atoms at positions 1 and 3. It is considered fairly rare in nature and its derivatives are also expected to be present in relatively low concentrations. This specific compound has the molecular formula C6H7ClN2O2S and it is used in a variety of chemical reactions, predominantly in laboratory settings for synthesis and research purposes. Its properties, like other chemicals, can vary significantly dependent on factors such as pH, temperature, and other chemical interactions.

InChI:InChI=1/C6H7ClN2O2S/c1-4-3-5(7)9-6(8-4)12(2,10)11/h3H,1-2H3

Upstream product

• 6328-58-1 4-Hydroxy-6-methyl-2-methylthiopyrimidine 
• 56-04-2 6-methyl-2-thiouracil 
• 17119-73-2 4-chloro-6-methyl-2-methylthiopyrimidine 

Relevant articles and documents

Synthesis of PF-6870961, a major hydroxy metabolite of the novel ghrelin receptor inverse agonist PF-5190457

Preclinical and human studies have indicated involvement of the ghrelin system in alcohol-related behaviors illuminating the possibility of using ghrelin receptor blockers as a pharmacological intervention for alcohol use disorder (AUD). Preliminary data from a recently conducted phase 1b human study with a ghrelin receptor inverse agonist, PF-5190457 (2-(2-methylimidazo[2,1-b][1,3thiazol-6-yl)-1-{2-(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-ylethanone), provided evidence on the safety and tolerability of this compound when co-administered with alcohol. Furthermore, the study revealed important information on the biotransformation pathways for this compound and prompted the discovery and then synthesis of a newly identified major metabolite, PF-6870961 ((R)-1-(2-(5-(2-hydroxy-6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethan-1-one). The metabolite was synthesized and fully characterized through a design that enabled it to be prepared in useful quantities. The synthesis provided direct access to the recently discovered PF-6870961 and is allowing researchers to conduct additional and deeper evaluation of its in vitro and in vivo properties.

2-benzyloxy-4-phenoxypyrimidine derivative, processes for producing the derivative and herbicidal composition containing the derivative

A 2-benzyloxy-4-phenoxypyrimidine derivative represented by the formula (I): STR1 wherein R1 represents hydrogen, a halogen, C1 -C4 alkyl, C1 -C4 haloalkyl, C1 -C4 alkoxy, C1 -C4 haloalkoxy, C3 -C5 alkenyloxy, C1 -C4 alkylthio, C1 -C4 haloalkylthio, cyano, or phenyl; each X, which may be identical or different if n is greater than 1, represents a halogen, C1 -C4 alkyl, C1 -C4 haloalkyl, or C1 -C4 alkoxy; each Y, which may be identical or different if m is greater than 1, represents a halogen, C1 -C4 alkyl, C1 -C4 haloalkyl, C1 -C4 alkoxy, C1 -C4 haloalkoxy, C1 -C4 alkylthio, or C1 -C4 haloalkylthio; and n and m each independently represent an integer of 0 to 5, which is useful as a herbicide.

O-alkyl-O-[4-alkylpyrimidin(2)yl]-(thiono)-(thiol) phosphoric (phosphonic) acid esters and insecticidal, acaricidal and nematocidal compositions containing them

O-Alkyl-O-[4-alkylpyrimidin(2)yl]-(thiono)-(thiol) phosphoric (phosphonic) acid esters of the formula STR1 in which R is alkyl with 1 to 9 carbon atoms, R1 is alkyl, alkoxy or alkylmercapto each with 1 to 6 carbon atoms, or phenyl, R2 is alkyl with 1 to 6 carbon atoms, R3 is hydrogen or halogen, R4 is halogen, thiocyanato or alkoxy, alkylmercapto or alkoxycarbonyl with 1 to 4 carbon atoms in each radical, and X is oxygen or sulfur, which possess insecticidal, acaricidal and nematocidal properties.