55329-22-1

Usage

Uses

Used in Chemical Synthesis:
4-Chloro-6-methyl-2-(methylsulfonyl)pyrimidine is used as a chemical intermediate for the synthesis of various compounds. Its unique structure and reactivity make it a valuable building block in the preparation of complex organic molecules.
Used in Research Applications:
4-CHLORO-6-METHYL-2-(METHYLSULFONYL)PYRIMIDINE is used as a research tool in the field of organic chemistry, particularly for studying the properties and reactions of pyrimidine derivatives. It can provide insights into the structure-activity relationships of these compounds and contribute to the development of new synthetic strategies and methodologies.
Used in Pharmaceutical Industry:
4-Chloro-6-methyl-2-(methylsulfonyl)pyrimidine may be used as a starting material or a key intermediate in the synthesis of potential drug candidates. Its unique chemical properties could be exploited to design and develop new therapeutic agents with novel mechanisms of action.
Used in Material Science:
4-CHLORO-6-METHYL-2-(METHYLSULFONYL)PYRIMIDINE may also find applications in the development of new materials, such as polymers or coordination complexes, where its unique structural features could impart specific properties or functions to the resulting materials.

InChI:InChI=1/C6H7ClN2O2S/c1-4-3-5(7)9-6(8-4)12(2,10)11/h3H,1-2H3

Upstream product

• 17119-73-2 4-chloro-6-methyl-2-methylthiopyrimidine 
• 56-04-2 6-methyl-2-thiouracil 
• 6328-58-1 4-Hydroxy-6-methyl-2-methylthiopyrimidine 

Relevant academic research and scientific papers

Synthesis of PF-6870961, a major hydroxy metabolite of the novel ghrelin receptor inverse agonist PF-5190457

Preclinical and human studies have indicated involvement of the ghrelin system in alcohol-related behaviors illuminating the possibility of using ghrelin receptor blockers as a pharmacological intervention for alcohol use disorder (AUD). Preliminary data from a recently conducted phase 1b human study with a ghrelin receptor inverse agonist, PF-5190457 (2-(2-methylimidazo[2,1-b][1,3thiazol-6-yl)-1-{2-(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-ylethanone), provided evidence on the safety and tolerability of this compound when co-administered with alcohol. Furthermore, the study revealed important information on the biotransformation pathways for this compound and prompted the discovery and then synthesis of a newly identified major metabolite, PF-6870961 ((R)-1-(2-(5-(2-hydroxy-6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethan-1-one). The metabolite was synthesized and fully characterized through a design that enabled it to be prepared in useful quantities. The synthesis provided direct access to the recently discovered PF-6870961 and is allowing researchers to conduct additional and deeper evaluation of its in vitro and in vivo properties.

Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors

By the screening of a combinatorial library for inhibitors of nitric oxide (NO) formation by the inducible isoform of nitric oxide synthase (iNOS) using a whole-cell assay, 2-(imidazol-1-yl)pyrimidines were identified. Compounds were found to inhibit the dimerization of iNOS monomers, thus preventing the formation of the dimeric, active form of the enzyme. Optimization led to the selection of the potent, selective, and orally available iNOS dimerization inhibitor, 21b, which significantly ameliorated adjuvant-induced arthritis in a rat model. Analysis of the crystal structure of the 21b-iNOS monomer complex provided a rationalization for both the SAR and the mechanism by which 21b blocks the formation of the protein-protein interaction present in the dimeric form of iNOS.

2-benzyloxy-4-phenoxypyrimidine derivative, processes for producing the derivative and herbicidal composition containing the derivative

A 2-benzyloxy-4-phenoxypyrimidine derivative represented by the formula (I): STR1 wherein R1 represents hydrogen, a halogen, C1 -C4 alkyl, C1 -C4 haloalkyl, C1 -C4 alkoxy, C1 -C4 haloalkoxy, C3 -C5 alkenyloxy, C1 -C4 alkylthio, C1 -C4 haloalkylthio, cyano, or phenyl; each X, which may be identical or different if n is greater than 1, represents a halogen, C1 -C4 alkyl, C1 -C4 haloalkyl, or C1 -C4 alkoxy; each Y, which may be identical or different if m is greater than 1, represents a halogen, C1 -C4 alkyl, C1 -C4 haloalkyl, C1 -C4 alkoxy, C1 -C4 haloalkoxy, C1 -C4 alkylthio, or C1 -C4 haloalkylthio; and n and m each independently represent an integer of 0 to 5, which is useful as a herbicide.

Herbicidal composition containing 2-benzyloxypyrimidine derivatives, processes for producing the derivatives and 2-benzyloxypyrimidine derivatives

A herbicidal composition comprising a herbicidally effective amount of a 2-benzyloxypyrimidine derivative represented by the formula (I): STR1 wherein R1 and R2 are each independently H, a halogen, hydroxyl, C1 -C4 alkyl, C1 -C4 haloalkyl, C3 -C5 alkenyl, C3 -C5 alkynyl, C1 -C4 alkoxy, C1 -C4 haloalkoxy, C3 -C5 alkenyloxy, C3 -C5 alkynyloxy, C1 -C4 alkylthio, or phenyl; n is an integer of 0 to 5; and each X which may be identical or different if n is greater than 1, is a halogen, C1 -C4 alkyl, C1 -C4 haloalkyl, C1 -C4 alkoxy, C1 -C4 alkylthio, C7 -C9 aralkyloxy, phenyl, hydroxymethyl, hydroxycarbonyl, C1 -C4 alkoxycarbonyl, or nitro, and an adjuvant.

O-alkyl-O-[4-alkylpyrimidin(2)yl]-(thiono)-(thiol) phosphoric (phosphonic) acid esters and insecticidal, acaricidal and nematocidal compositions containing them

O-Alkyl-O-[4-alkylpyrimidin(2)yl]-(thiono)-(thiol) phosphoric (phosphonic) acid esters of the formula STR1 in which R is alkyl with 1 to 9 carbon atoms, R1 is alkyl, alkoxy or alkylmercapto each with 1 to 6 carbon atoms, or phenyl, R2 is alkyl with 1 to 6 carbon atoms, R3 is hydrogen or halogen, R4 is halogen, thiocyanato or alkoxy, alkylmercapto or alkoxycarbonyl with 1 to 4 carbon atoms in each radical, and X is oxygen or sulfur, which possess insecticidal, acaricidal and nematocidal properties.