5533-04-0

Basic information

• Product Name: Benzaldehyde, 2-(methoxymethoxy)-
• CAS NO: 5533-04-0
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Mol File: 5533-04-0.mol
• Article Data: 58

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2-(methoxymethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2-(methoxymethoxy)-(5533-04-0)
• EPA Substance Registry System: Benzaldehyde, 2-(methoxymethoxy)-(5533-04-0)

Safety Data

• Hazardous Substances Data: 5533-04-0(Hazardous Substances Data)

Upstream product

• 542-88-1 bis(2-chloromethyl)ether 
• 90-02-8 salicylaldehyde 
• 106-44-5 p-cresol 
• 107-30-2 chloromethyl methyl ether 
• 13057-17-5 bromethyl methyl ether 
• 89-95-2 2-methyl-benzyl alcohol 
• 25458-49-5 1-(methoxymethoxy)-4-methylbenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 824-91-9 O-methoxymethylphenol 

Downstream Products

• 110048-26-5 2'-hydroxy-4',6'-dimethoxy-2-methoxymethoxy-trans-chalcone 
• 368447-69-2 2-methoxymethoxybenzaldehyde (E)-O-[(1S)-2-hydroxy-1-phenylethyl]oxime 
• 693794-59-1 1-(2,2-dibromovinyl)-2-(methoxymethoxy)-benzene 
• 26962-50-5 isoliquiritigenin 
• 89-95-2 2-methyl-benzyl alcohol 
• 251909-33-8 2,4'-di-O-methoxymethyl-retro-chalcone 
• 209404-21-7 2-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-3-(4-methoxy-2-methoxymethoxy-phenyl)-propionic acid methyl ester 
• 1589000-84-9 (R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane 
• 1589000-86-1 (R)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propan-1-ol 
• 1589000-55-4 (S)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propanal 
• 1589000-58-7 4-bromo-2-(methoxymethoxy)phenol 
• 209404-19-3 2-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-3-(2-methoxymethoxy-phenyl)-propionic acid methyl ester 
• 201049-10-7 (E)-3-(2-(methoxymethoxy)phenyl)-1-(4-methoxyphenyl)prop-2-en-1-one 

Relevant articles and documents

Cationic Alkynyl Heck Reaction toward Substituted Allenes Using BobCat: A New Hybrid Pd(0)-Catalyst Incorporating a Water-Soluble dba Ligand

The cationic alkynyl Heck reaction between aryl triflates and alkynes to give substituted allenes is described. Key to the success of this method was the discovery and development of a new hybrid Pd(0)-catalyst, BobCat, that incorporates a water-soluble dba-ligand and biaryl phosphine ligand to provide substituted allenes in good yields under mild reaction conditions.

68Ga-Labelled Tropane Analogues for the Visualization of the Dopaminergic System

The development of radiometal-labelled pharmaceuticals for neuroimaging could offer great potential due to easier handling during labelling and availability through radionuclide generator systems. Nonetheless, to date, no such tracers are available for positron emission tomography, primarily owing to the challenge of crossing the blood–brain barrier (BBB) and loss of affinity through chelator attachment. We have prepared a variety of 68Ga-labelled phenyltropanes showing that, through a simple hydrocarbon-linker, it is possible to introduce a chelator onto the lead structure while maintaining its high affinity for hDAT (human dopamine transporter) and simultaneously achieving adequate lipophilicity. One of the candidates, [68Ga]Ga-HBED-hexadiyne-tropane, showed an IC50 value of 66 nM, together with a log D7.4 of 0.96. A μPET study in a hemi-parkinsonian rat model showed a fast wash-out of the tracer, and no specific uptake in the brain, thus implying an inability to penetrate the BBB.

Facile Synthesis of 2-Fluorobenzofurans: 5-endo-trig Cyclization of β,β-Difluoro-o-hydroxystyrenes

Efficient synthetic methods were established for obtaining 2-fluorobenzofurans involving various substituents. Upon being treated with 1,8-diazabicyclo[5.4.0]undec-7-ene under microwave irradiation, the α-unsubstituted β,β-difluoro-o-hydroxystyrenes under