55332-35-9

Usage

Uses

Used in Pharmaceutical Industry:
(S)-(+)-2-ISOPROPYL-2-(4-METHYLPHENYL)ACETIC ACID is used as a chiral molecule for its potential therapeutic properties. Its structural similarity to ibuprofen, a widely used medication for pain, fever, and inflammation relief, positions it as a candidate for developing new drugs with similar or improved effects.
Used in Anti-inflammatory and Analgesic Applications:
In the field of medicine, (S)-(+)-2-ISOPROPYL-2-(4-METHYLPHENYL)ACETIC ACID is used as an active compound for its anti-inflammatory and analgesic effects. Its potential to alleviate pain and reduce inflammation makes it a valuable asset in the development of novel medications for various conditions.
Used in Drug Development:
(S)-(+)-2-ISOPROPYL-2-(4-METHYLPHENYL)ACETIC ACID is employed as a key component in drug development, where its unique properties and biological activity are harnessed to create innovative pharmaceuticals. Ongoing research seeks to optimize its use and maximize its therapeutic potential in treating various medical conditions.

Upstream product

• 33131-45-2 2-p-Toluyl-3-methylcrotonsaeure 

Relevant academic research and scientific papers

Enantioselective Hydrogenation of Tetrasubstituted α,β-Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights

Chiral carboxylic acids are important compounds because of their prevalence in pharmaceuticals, natural products and agrochemicals. Asymmetric hydrogenation of α,β-unsaturated carboxylic acids has been widely recognized as one of the most efficient synthetic approaches to afford such compounds. Although related asymmetric hydrogenation of di- and trisubstituted unsaturated acids with noble metals is well established, asymmetric hydrogenation of challenging tetrasubstituted α,β-unsaturated carboxylic acids is rarely reported. We demonstrate enantioselective hydrogenation of cyclic and acyclic tetrasubstituted α,β-unsaturated carboxylic acids via cobalt(II) catalysis. This protocol showed broad substrate scope and gave chiral carboxylic acids in good yields with excellent enantiocontrol (up to 98 % yield and 99 % ee). Combined experimental and computational mechanistic studies support a CoII catalytic cycle involving migratory insertion and σ-bond metathesis processes. DFT calculations reveal that enantioselectivity may originate from the steric effect between the phenyl groups of the ligand and the substrate.

Synthesis of Optically Active α-Isopropyl-4-substituted Phenylacetic Acids by Asymmetric Hydrogenation

Homogeneous hydrogenation of 2-phenyl-3-methyl-2-butenoic acid derivatives in the presence of a catalytic amount of such chiral phosphine-rhodium complexes as Rh/(R)-BINAP, Rh/(R)-, or (S)-Cy-BINAP, Rh/(R)-p-tolyl-BINAP, and Rh/(R)-p-methoxyphenyl-BINAP afforded the corresponding phenylacetic acid derivatives in high enantiomeric excesses and in quantitative chemical yields.The optically activa phenylacetic acid derivatives are useful intermediates of agrochemicals and pharmaceuticals.