55340-40-4

Basic information

• Product Name: N-{10-[(2-hydroxyethyl)amino]-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl}acetamide
• Synonyms: N-[(7S)-10-(2-hydroxyethylamino)-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• CAS NO: 55340-40-4
• Molecular Formula: C₂₃H₂₈N₂O₆
• Molecular Weight: 428.4782
• Mol File: 55340-40-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 781.4°C at 760 mmHg
• Flash Point: 426.4°C
• Density: 1.28g/cm³
• Vapor Pressure: 1.04E-25mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: N-{10-[(2-hydroxyethyl)amino]-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{10-[(2-hydroxyethyl)amino]-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl}acetamide(55340-40-4)
• EPA Substance Registry System: N-{10-[(2-hydroxyethyl)amino]-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl}acetamide(55340-40-4)

Safety Data

• Hazardous Substances Data: 55340-40-4(Hazardous Substances Data)

Upstream product

• 209810-38-8 N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl) acetamide 
• 141-43-5 ethanolamine 
• 64-86-8 colchicine 

Relevant articles and documents

Synthesis and antitumour activity of novel colchicine C-10 derivatives

A series of new colchicine C-10 derivatives (2a-i, 3a-h) were synthesized by replacement of the 10-methoxy with NR2 and SCH3 in order to determine their cytotoxic activity. The compounds were synthesized in good yield and the structures of all newly synthesized compounds were established on the basis of their IR, 1H NMR and elemental analysis. The synthesized compounds were tested in vitro antitumor activity against four human cancer cell lines by MTT assay. It was found that many of the derivatives displayed significant activity, particularly, compound 2a and 2b showed more potent cytotoxic activities than colchicine.

Aziridine and hydroxy- and chloroethylamine derivatives of colchicine and their biological activity

With the aim of enhancing the cytostatic properties of the initial alkaloid, new aziridine and bis(chloroethyl)amine derivatives of colchicine have been synthesized by the direct interaction of colchicine with chloroethylamine hydrochloride and also via the mono-and diethanolamine derivatives. The structures of the compounds obtained have been studied by spectral methods. An increased radiomodifying and antitumoral activity and a decreased toxicity of the substances synthesized as compared with the initial colchicine has been shown. Results obtained in the National Cancer Institute of the USA from the study of the cytostatic activity of the bis(chloroethyl)amino derivative of 60 tumor lines are presented.