553652-34-9

Usage

Uses

Used in Organic Synthesis:
NBS is used as a reagent for selective bromination at allylic and benzylic positions, allowing chemists to introduce bromine atoms into specific locations within organic molecules. This selective bromination is crucial for the synthesis of complex organic compounds and the development of new pharmaceuticals and materials.
Used in the Formation of Carbon-Bromine Bonds:
NBS serves as a mild and convenient source of bromine for the formation of carbon-bromine bonds in various synthetic applications. This is particularly useful in the synthesis of organic compounds that require bromine atoms for their biological activity or chemical properties.
Used as a Bleaching Agent:
In the food industry, NBS is utilized as a bleaching agent for edible oils and fats. Its ability to bleach these products enhances their appearance and extends their shelf life, making it a valuable component in food processing.
Safety Precautions:
It is important to handle NBS with care, as it can be a mild irritant to the skin, eyes, and respiratory system. Proper safety measures, such as wearing protective clothing and using appropriate ventilation, should be taken to minimize potential health risks during its use in laboratory and industrial settings.

Upstream product

• 615-36-1 2-bromoaniline 
• 116547-91-2 N-(2-bromophenyl)methanesulfonamide 
• 74-88-4 methyl iodide 

Downstream Products

• 1257706-93-6 N-{2-[(E)-2-(2-chloro-[1,2,4]triazolo[1,5-a]pyridin-8-yl)vinyl]phenyl}-N-methyl-methanesulfonamide 
• 1372590-44-7 N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl)acetamide 
• 1372590-74-3 1-methyl-N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl)piperidine-4-carboxamide 
• 1372590-77-6 N-(3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl)-4-(2-oxopyrrolidin-1-yl)butanamide 
• 24827-66-5 1-methyl-1,3-dihydrobenzo[c]isothiazole-2,2-dioxide 
• 1257705-85-3 N-methyl-N-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-methane-sulfonamide 

Relevant academic research and scientific papers

CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF

Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b' to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.

FUSED RING PYRIMIDINE COMPOUND, INTERMEDIATE, AND PREPARATION METHOD, COMPOSITION AND USE THEREOF

Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.

Synthesis of spiropyrrolidinyl-benzoisothiazoline derivatives by 1,3-dipolar cycloaddition of benzoisothiazole-2,2-dioxide-3-ylidenes and azomethine ylide

The new spirocyclic compounds, spiropyrrolidinyl-benzoisothiazoline derivatives were synthesized by the 1,3-dipolar cycloaddition of benzoisothiazole-2,2-dioxide-3-ylidenes and azomethine ylide. The stereochemistry of 1,3-dipolar cycloaddition as well as the stereochemistry of Knoevenagel condensation of benzoisothiazole-2,2-dioxide with aldehydes were studied.

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES

This application relates to compounds of the general Formula I and salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.