55389-14-5

Basic information

• Product Name: 2-bromo-5-fluorobenzenethiol
• Synonyms: 2-bromo-5-fluorobenzenethiol
• CAS NO: 55389-14-5
• Molecular Formula: C6H4BrFS
• Molecular Weight: 207.066
• Mol File: 55389-14-5.mol

Chemical Properties

• CAS DataBase Reference: 2-bromo-5-fluorobenzenethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-5-fluorobenzenethiol(55389-14-5)
• EPA Substance Registry System: 2-bromo-5-fluorobenzenethiol(55389-14-5)

Safety Data

• Hazardous Substances Data: 55389-14-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-bromo-5-fluorobenzenethiol is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with specific therapeutic or pesticidal properties.
Used in Materials Science:
In the field of materials science, 2-bromo-5-fluorobenzenethiol is utilized for the development of polymers and other advanced materials. Its halogenated nature and aromatic structure contribute to the creation of materials with tailored properties for specific applications.
Used in Animal Behavior Studies:
2-bromo-5-fluorobenzenethiol's strong odor makes it suitable for use in scent-marking studies within the field of animal behavior. Researchers can utilize 2-bromo-5-fluorobenzenethiol to investigate the role of olfactory cues in animal communication and territorial marking.

Upstream product

• 147460-41-1 2-bromo-5-fluorophenol 
• 147460-40-0 1-(2-bromo-5-fluorophenoxy)-N,N-dimethylmethanethioamide 
• 147460-42-2 1-[(2-bromo-5-fluorophenyl)sulfanyl]-N,N-dimethylformamide 

Downstream Products

• 1026698-15-6 1-(2-bromo-5-fluoro-phenylsulfanyl)-6-chloro-hexan-2-one 
• 147460-43-3 1-bromo-4-fluoro-2-(methylsulfanyl)benzene 
• 263863-22-5 4-[(S)-2-methylsulfinyl-4-fluorophenyl]piperidine 
• 439942-28-6 4-(4-fluoro-2-methylsulfanyl-phenyl)-4-hydroxy-piperidine-1-carboxylic acid benzyl ester 
• 1027424-26-5 4-[4-Fluoro-2-((S)-methanesulfinyl)-phenyl]-piperidine-1-carboxylic acid benzyl ester 
• 324768-97-0 2-(2-bromo-5-fluorophenylthio)acetaldehyde diethylacetal 
• 324768-96-9 7-bromo-4-fluoro-1-benzothiophene 
• 664364-71-0 1-bromo-2-[(2,2-dimethoxyethyl)sulfanyl]-4-fluorobenzene 

Relevant articles and documents

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Through optimization of compounds based on the dual NK1/NK2 antagonist ZD6021, it was found that alteration of two key regions could modulate the balance of NK1 and NK2 potency. Substitution of the 2-naphthalene position in analogues of ZD6021 resulted in increased NK1 potency and thus afforded NK1 preferential antagonists. Alterations of the piperidine region could then increase NK2 potency to restore dual NK1/NK2 selectivity. Through these efforts, three novel receptor antagonists from a single chemically related series were identified; two are dual NK1/NK2 antagonists, and the third is an NK1 preferential antagonist. In this paper, the factors affecting the balance of NK1 and NK2 selectivity in this series are discussed and the in vitro and in vivo properties of the novel antagonists are described.