55394-52-0Relevant academic research and scientific papers
Synthesis and Anticancer Evaluation of Amide Derivatives of 1,3,4-Oxadiazole Linked with Benzoxazole
Ravinaik,Ramachandran,Rao, M. V. Basaveswara
, p. 1003 - 1008 (2019)
A novel series of amide 1,3,4-oxadiazole linked benzoxazole derivatives 12a–12j are synthesized and their anticancer activity is screened against four human cancer cell lines including A549 (Lung cancer), MCF7 (Breast cancer), A375 (Melanoma cancer), HT-29 (Colon cancer) using Combretastatin-A4 as a control drug. Among the synthesized compounds, 12c and 12g demonstrate potent anticancer activity against HT-29 cancer cell line with IC50 values of 0.018 and 0.093 μM, respectively, which is higher than the standard drug.
