55409-19-3

Upstream product

• 96-09-3 styrene oxide 
• 625-35-4 trans-chrotonyl chloride 
• 588-67-0 benzyl 1-butyl ether 
• 16224-09-2 benzyl cyclohexyl ether 
• 14593-43-2 benzyl allyl ether 
• 14289-64-6 allyl cyclohexyl ether 
• 940-49-8 benzyl iso-butyl ether 
• 122-60-1 Phenyl glycidyl ether 
• 286-20-4 cyclohexane-1,2-epoxide 
• 13154-14-8 1-propenylmagnesium bromide 
• 30094-01-0 (E)-(2-phenylethenyl)magnesium bromide 
• 59417-06-0 1,4-dimethyl-2,3-dioxopiperazine 

Relevant academic research and scientific papers

Preparation of a cycloheptane ring from a 1,2-diketone with high stereoselectivity

Treatment of 1,6-dialkylhexa-1,5-diene-3,4-diones with bis(iodozincio) methane gave zinc alkoxides of cis-5,6-dialkylcyclohepta-3,7-diene-1,3-diol in good yields at room temperature. The reaction proceeded with high stereospecificity. Bis(iodozincio)metha

Cobalt(II)chloride catalysed cleavage of ethers with acyl halides: Scope and mechanism

Cobalt(II) chloride in acetonitrile catalyses the cleavage of a wide variety of ethers with acyl halides under mild conditions to give the corresponding esters in good yields. Acyclic aliphatic ethers are cleaved to the corresponding ester and chlorides whereas the cyclic aliphatic ethers give rise to the ω-chloroesters. The benzyl ethers can be converted to the corresponding esters along with the formation of benzyl chloride and benzyl acetamide. A comparative study for the cleavage of allyl and benzyl ether has revealed that benzyl ether can be selectively cleaved in presence of the allyl ethers. The oxiranes can be cleaved in highly regioselective manner to the corresponding-β-chloroesters. The vinyl ethers undergo sp2-hybridised carbon-oxygen bond cleavage under these conditions. Based on product analysis, a mechanism involving electron transfer followed by O-acylation and S(N)1 or S(N)2 attack by chloride-ion is discussed.