55409-87-5 Usage
Uses
Used in Coordination Chemistry:
3-(3-Methoxypropyl)-1-phenylthiourea is used as a ligand in coordination chemistry for its ability to form stable complexes with metal ions. This property is valuable in the development of new materials with specific properties, such as catalysts, sensors, and functional materials.
Used in Organic Synthesis:
In the field of organic synthesis, 3-(3-Methoxypropyl)-1-phenylthiourea serves as a reagent, facilitating various chemical reactions and transformations. Its unique structure allows it to participate in a range of reactions, contributing to the synthesis of complex organic molecules and pharmaceutical compounds.
Used in Pharmaceutical Industry:
3-(3-Methoxypropyl)-1-phenylthiourea may have potential applications in the pharmaceutical industry due to its structural properties. Its ability to form stable complexes and participate in various chemical reactions could make it a valuable component in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Similarly, 3-(3-Methoxypropyl)-1-phenylthiourea may also find use in the agrochemical industry, where its structural properties could be leveraged for the development of new pesticides, herbicides, or other agricultural chemicals.
Safety Precautions:
It is important to handle 3-(3-Methoxypropyl)-1-phenylthiourea with care, as it may pose health risks if not used properly. Appropriate safety precautions should be taken when working with 3-(3-Methoxypropyl)-1-phenylthiourea to minimize potential hazards and ensure the safety of individuals involved in its production, handling, and application.
Check Digit Verification of cas no
The CAS Registry Mumber 55409-87-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,0 and 9 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 55409-87:
(7*5)+(6*5)+(5*4)+(4*0)+(3*9)+(2*8)+(1*7)=135
135 % 10 = 5
So 55409-87-5 is a valid CAS Registry Number.
55409-87-5Relevant academic research and scientific papers
Design, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells
Zhou, Hongyu,Wu, Shuhong,Zhai, Shumei,Liu, Aifeng,Sun, Ying,Li, Rongshi,Zhang, Ying,Ekins, Sean,Swaan, Peter W.,Fang, Bingliang,Zhang, Bin,Yan, Bing
, p. 1242 - 1251 (2008/12/23)
Ten cytoselective compounds have been identified from 372 thiazolidinone analogues by applying iterative library approaches. These compounds selectively killed both non-small cell lung cancer cell line H460 and its paclitaxel-resistant variant H460taxR at an IC50 between 0.21 and 2.93 μM while showing much less toxicity to normal human fibroblasts at concentrations up to 195 μM. Structure-activity relationship studies revealed that (1) the nitrogen atom on the 4-thiazolidinone ring (ring B in Figure 1) cannot be substituted, (2) several substitutions on ring A are tolerated at various positions, and (3) the substitution on ring C is restricted to the -NMe2 group at the 4-position. A pharmacophore derived from active molecules suggested that two hydrogen bond acceptors and three hydrophobic regions were common features. Activities against P-gp-overexpressing and paclitaxel-resistant cell line H460taxR and modeling using a previously validated P-gp substrate pharmacophore suggested that active compounds were not likely P-gp substrates.
