55411-39-7Relevant academic research and scientific papers
Improved compsn. antiallergic habitus
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, (2007/10/06)
PROBLEM TO BE SOLVED: To provide a composition for ameliorating allergic constitution naturally ingestible in daily life. SOLUTION: The composition for ameliorating the allergic constitution comprises a galactooligosaccharide as a main ingredient. Furthermore, a food and drink uses the composition. Since the galactooligosaccharide is already widely used in heath-oriented foods such as a specific food for health and is a material in which the safety is sufficiently established, the galactooligosaccharide is naturally ingestible over a long period in the daily life. COPYRIGHT: (C)2007,JPOandINPIT
Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies
Johnson, Steven M.,Connelly, Stephen,Wilson, Ian A.,Kelly, Jeffery W.
supporting information; experimental part, p. 1115 - 1125 (2009/12/24)
Transthyretin (TTR) amyloidogenesis inhibitors are typically composed of two aromatic rings and a linker. We have previously established optimal structures for one aromatic ring and the linker. Herein, we employ a suboptimal linker and an optimal aryl-X substructure to rank order the desirability of aryl-Z substructures-using a library of 56 N-(3,5-dibromo-4-hydroxyphenyl) benzamides. Coconsideration of amyloid inhibition potency and ex vivo plasma TTR binding selectivity data reveal that 2,6, 2,5, 2, 3,4,5, and 3,5 substituted aryls bearing small substituents generate the most potent and selective inhibitors, in descending order. These benzamides generally lack undesirable thyroid hormone receptor binding and COX-1 inhibition activity. Three high-resolution TTR ? inhibitor crystal structures (1.31-1.35 ?) provide insight into why these inhibitors are potent and selective, enabling future structure-based design of TTR kinetic stabilizers.
Pharmaceutical method for the therapy of immune diseases
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, (2008/06/13)
Compounds having the formula STR1 (the meanings of R1, R2, R3, R4 and R5 are indicated hereinafter) exhibit suppressive activity to various immune responses and can be employed in the therapy of immun
Treatment of elevated histamine and uric acid levels
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, (2008/06/13)
Compounds having the general formula SPC1 (the meanings of R1, R2, R3, R4 and R5 are indicated hereinafter) and the pharmaceutically acceptable salts and esters thereof exhibit strong activities in inhibiting histidine decarboxylase and xanthine oxidase. One example is the compound of the formula SPC2
