55418-27-4

Basic information

• Product Name: O-[(2-FLUOROPHENYL)METHYL]-HYDROXYLAMINE
• Synonyms: HYDROXYLAMINE, O-[(2-FLUOROPHENYL)METHYL]-;O-[(2-FLUOROPHENYL)METHYL]-HYDROXYLAMINE;OTAVA-BB 1206572;2-Fluorobenzylhydroxylamine;O-(2-Fluorobenzyl)hydroxylamine;2-FluorobenzylhydroxylaMine hydrochloride;2-Fluoro-benzyloxylaminehydrocheloride
• CAS NO: 55418-27-4
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.144
• Mol File: 55418-27-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 238℃
• Flash Point: 98℃
• Appearance: /
• Density: 1.176
• CAS DataBase Reference: O-[(2-FLUOROPHENYL)METHYL]-HYDROXYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: O-[(2-FLUOROPHENYL)METHYL]-HYDROXYLAMINE(55418-27-4)
• EPA Substance Registry System: O-[(2-FLUOROPHENYL)METHYL]-HYDROXYLAMINE(55418-27-4)

Safety Data

• Hazardous Substances Data: 55418-27-4(Hazardous Substances Data)

Usage

General Description

O-[(2-Fluorophenyl)methyl]-hydroxylamine is a chemical compound with the molecular formula C7H8FNO. It is an organic compound that contains a hydroxylamine functional group, which consists of a nitrogen atom covalently bonded to a hydrogen and an oxygen atom. O-[(2-FLUOROPHENYL)METHYL]-HYDROXYLAMINE is commonly used in organic synthesis and as a reagent in chemical reactions, particularly in the preparation of pharmaceuticals and agrochemicals. It has also been investigated for its potential antimicrobial and antiviral properties. The presence of the fluorophenyl group in the molecule contributes to its unique reactivity and properties, making it a valuable building block for the synthesis of various organic compounds.

Upstream product

• 446-51-5 2-fluorobenzyl alcohol 
• 55418-28-5 2-(2-fluorobenzyloxy) isoindoline-1,3-dione 

Downstream Products

• 681144-88-7 2-[2-(2-fluoro-benzyloxyamino)-ethyl]-isoindole-1,3-dione 
• 215599-91-0 O-(2-fluorobenzyl)hydroxylamine hydrochloride 
• 1299491-46-5 4,5-dibromo-1H-pyrrole-2-carboxylic acid (2-fluorobenzyloxy)amide 
• 1207383-20-7 (4Z)-6-(4-chlorophenyl)-1,3-oxazinane-2,4-dione-4-[O-(2-fluorobenzyl)oxime] 
• 681152-45-4 1-(2-fluoro-benzyloxy)-4,5-dihydro-1H-imidazole-2-thiol 
• 681146-97-4 N-(2-amino-ethyl)-O-(2-fluoro-benzyl)-hydroxylamine 

Relevant articles and documents

N-(benzyloxy)-2-chloronicotinamide compound as well as preparation method and application thereof

The invention belongs to the technical field of chemical synthesis and medicine application, and particularly relates to preparation and application of an N-(benzyloxy)-2-chloronicotinamide compound. The preparation method comprises the following steps: reacting phthalic anhydride with hydroxylamine, then reacting with triethylamine for acidification to prepare N-hydroxyphthalimide, then carrying out substitution and hydrazinolysis, and finally reacting with dichloronicotinoyl chloride to prepare the N-(benzyloxy)-2-chloronicotinamide compound. The preparation method disclosed by the invention is simple and convenient to operate, the structure of the obtained product is confirmed by a nuclear magnetic hydrogen spectrum, herbicidal activity tests are carried out on the obtained 15 target products, and results show that all target compounds have an obvious inhibition effect on the seeds of the Agrostis matsumurae under the concentration of 1mM, and the inhibition effect reaches 100%; and along with the decrease of the concentration, even if the concentration reaches 100 [mu] M, the target compound can still show good herbicidal activity.

Design, synthesis, molecular docking and biological evaluation of novel coumarin-oxime ether derivatives as COX-2 inhibitors

Coumarin-oxime ether derivatives (14-25) were synthesized by an efficient and straight forward procedure from the reaction of 3-acetyl coumarin (1) and o-substituted benzyl hydroxyl amines (2-13) in pyridinium p-toluenesulfonate/dichloromethane (PPTS/DCM)

Transformation of masked benzyl alcohols to: O -aminobenzaldehydes through C-H activation: A facile approach to quinazolines

Direct transformation of a directing group to important synthetic units would provide a high atom efficiency synthetic approach in synthetic chemistry. Herein, a convenient protocol for the synthesis of o-aminobenzaldehyde and benzoxazole derivatives from benzyl alcohols has been developed by employing (N,N-dimethyl)oxamoyl amide as a directing group in a palladium-catalyzed intramolecular amination. Furthermore, the attached directing center may not only be transformed into the product, but may also be further applied to generate synthetically important quinazoline and quinoline units. Finally, a high atom efficiency one-pot, two-step approach to form quinazolines from benzyl alcohol derivatives has been achieved in good yields, thus demonstrating its high utility.