55424-49-2Relevant academic research and scientific papers
Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant
Berggren, Kristina,Johansson, Bjoern,Fex, Tomas,Kihlberg, Jan,Bjoerck, Lars,Luthman, Kristina
experimental part, p. 3463 - 3470 (2009/09/25)
Analogues of the irreversible protease inhibitors TPCK and TLCK have been synthesized and tested as inhibitors of the bacterial cysteine protease IdeS excreted by Streptococcus pyogenes. Eight compounds were identified as inhibitors of IdeS in an in vitro
