55431-77-1

Usage

Class

Anthracenediones

Function

Cytotoxic chemotherapy drug

Usage

Treatment of various types of cancer, including lung cancer, testicular cancer, and lymphomas

Mechanism of Action

Inhibits the enzyme topoisomerase II, disrupting DNA replication and repair

Effect on Cell Cycle

Triggers the death of cancer cells by blocking topoisomerase II

Side Effects

Bone marrow suppression, increased risk of developing secondary cancers

Importance

Widely used treatment option for cancer patients despite potential risks

Upstream product

• 1165952-91-9 cyclohexa-1,3-diene 
• 106-51-4 p-benzoquinone 
• 130-15-4 [1,4]naphthoquinone 

Downstream Products

• 84-65-1 9,10-phenanthrenequinone 
• 75171-67-4 exo-1,4,4a,9a-tetrahydro-4a,9a-epoxy-1,4-ethano-9,10-anthraquinone 
• 75102-24-8 endo-1,4,4a,9a-tetrahydro-4a,9a-epoxy-1,4-ethano-9,10-anthraquinone 
• 75102-20-4 1,4-dihydro-9,10-dimethoxy-1,4-ethanoanthracene 
• 32740-61-7 1,4-Ethano-1,4-dihydro-9,10-anthraquinone 
• 55431-78-2 1,4,4a,9,9a,10-Hexahydro-1,4-ethano-anthracene-9,10-diol 

Relevant academic research and scientific papers

Hydrothermal synthesis of imidazole functionalized carbon spheres and their application in catalysis

We describe the production and catalytic application of highly functionalized mesoporous carbonaceous materials, obtained via a one step green and cheap process relying on the hydrothermal carbonization of carbohydrates (e.g. glucose) in the presence of functional organic monomers (e.g. vinyl imidazole). The resulting materials could be further functionalized to feature imidazolium bromides on their surface and be used for various transesterification, Knoevenagel and Aldol reactions.

Metal-free activation of C-C multiple bonds through halide ion pairs: Diels-Alder reactions with subsequent aromatization

Imidazolium and ammonium halides, both in homogeneous phase or immobilized on mesoporous silica, proved able to promote the aromatization reaction of Diels-Alder adducts under ethylene and H2 elimination. These observations point to the increased nucleophilicity of such halide ions. They also open the possibility to employ such ion pairs as nucleophilic organocatalysts, for example, as substitutes for phosphines or amines.