55432-25-2

Basic information

• Product Name: N-cyclopentyl-2-nitroaniline
• Synonyms: N-cyclopentyl-2-nitroaniline
• CAS NO: 55432-25-2
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.24106
• Mol File: 55432-25-2.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-cyclopentyl-2-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclopentyl-2-nitroaniline(55432-25-2)
• EPA Substance Registry System: N-cyclopentyl-2-nitroaniline(55432-25-2)

Safety Data

• Hazardous Substances Data: 55432-25-2(Hazardous Substances Data)

Upstream product

• 1493-27-2 ortho-nitrofluorobenzene 
• 1003-03-8 Cyclopentamine 
• 609-73-4 o-nitroiodobenzene 
• 88-73-3 2-Chloronitrobenzene 

Downstream Products

• 1449690-81-6 C₂₀H₃₀N₂O₃ 
• 600725-69-7 N-cyclopentyl-o-phenylenediamine 

Relevant articles and documents

Design, synthesis, and biological evaluation of 4-phenoxyquinoline derivatives as potent c-Met kinase inhibitor

A series of novel 4-phenoxyquinoline derivatives containing 3-oxo-3,4-dihydro-quinoxaline moiety were synthesized and evaluated for their antiproliferative activity against five human cancer cell lines (A549, H460, HT-29, MKN-45 and U87MG) in vitro. Most of the tested compounds exhibited more potent inhibitory activities than the positive control foretinib. Compound 1b, 1s and 1t were further examined for their inhibitory activity against c-Met kinase. The most promising compound 1s (with c-Met IC50 value of 1.42 nM) showed remarkable cytotoxicity against A549, H460, HT-29, MKN45 and U87MG cell lines with IC50 values of 0.39 μM, 0.18 μM, 0.38 μM, 0.81 μM, respectively. Their preliminary structure-activity relationships (SARs) study indicated that the replacement of the aromatic ring with the cyclohexane improved their antiproliferative activity.

Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents

A series of benzimidazole based HDAC inhibitors have been rationally designed, synthesized and screened. The SAR of this new chemotype is described. The lead compound, 11e, showed strong activity in several cellular assays and demonstrated in vivo efficacy in mouse xenograft pancreatic cancer models.

C-N bond formation catalysed by CuI Bonded to polyaniline nanofiber

Polyaniline nanofiber as a macroligand for the supported cuprous iodide catalyst (CuI-PANInf) has been developed for the coupling of aryl halides (including aryl chlorides) with aliphatic, aromatic, and N(H)-heterocyclic amines under ambient conditions (80 °C for aryl chlorides) has been developed. This simple and efficient method for coupling reactions is highly versatile, convenient, and also the catalyst can be used for several cycles with good-to-excellent yields.