55434-77-0

Upstream product

• 61199-39-1 1,5,1',5'-tetraphenyl-1H,1'H-3,3'-disulfanediyl-bis-[1,2,4]triazole 
• 420-04-2 CYANAMID 
• 4903-36-0 N-phenyl-benzimidoyl chloride 
• 62302-16-3 5-amino-2,3-diphenyl-[1,2,4]thiadiazolium; chloride 
• 38430-05-6 (E)-N-phenylbenzimidoyl chloride 
• 6041-23-2 methyl N-cyanobenzenecarboximidoate 
• 62-53-3 aniline 

Downstream Products

• 55434-83-8 N-(6-chloro-2-morpholin-4-yl-quinazolin-4-yl)-N'-phenyl-benzamidine 
• 55434-85-0 N-(2-morpholin-4-yl-quinazolin-4-yl)-N'-phenyl-benzamidine 
• 55434-87-2 N-methyl-N'(8-methyl-2-morpholin-4-yl-quinazolin-4-yl)-benzamidine 
• 55434-84-9 N-(2-morpholin-4-yl-benzo[h]quinazolin-4-yl)-N'-phenyl-benzamidine 
• 55434-81-6 N-(6-chloro-5,8-dimethyl-2-morpholin-4-yl-quinazolin-4-yl)-N'-phenyl-benzamidine 
• 55434-86-1 N-(8-methyl-2-morpholin-4-yl-quinazolin-4-yl)-N'-phenyl-benzamidine 

Relevant academic research and scientific papers

Synthesis of aroylguanidines by an unexpected demethylation-addition cascade

A simple and efficient method was developed for the synthesis of N-aroyl-N′-arylguanidines under mild conditions by an unexpected demethylation-addition cascade reaction of readily available N-cyanoimidates with aryl amines. Moreover, 1-aryl-2-aminoquinazolin-4(1H)-ones and 2-(arylamino)quinazolin-4(3H)-ones can also be prepared by selective cyclization reactions of (2-fluorobenzoyl)- or (2-nitrobenzoyl)guanidines, respectively. This method provided two attractive strategies for the preparation 2-aminoquinazolinones derivatives from inexpensive reactants.

SYNTHESIS OF SYMMETRICAL 1,6-DIHETERO-6aλ4-THIA-3,4-DIAZAPENTALENES FROM 5-AMINO-1,2,3,4-THIATRIAZOLE

1,6-Dioxa-6aλ4-thia-3,4-diazapentalenes 7 and 1,3,4,6-tetraaza-6aλ4-thiapentalenes 15, two new classes of compounds with single bond - no bond resonance, have been prepared by reaction of 5-amino-1,2,3,4-thiatriazole 4 with acyl chlorides and imidoyl chlorides.In the latter case, the salts of 5-imino-Δ3-1,2,4-thiadiazolines 12 were first isolated and subsequently reacted with a second equivalent of imidoyl chloride.This also led to the synthesis of unsimmetrically substituted 1,3,4,6-tetraaza-6aλ4-thiapentalenes.In the presence of bases, the salts 12 decompose via the isolable free bases 13 into N-cyanoamidines 14 and sulfur.Treatment of the dioxathiapentalenes 7 with P4S10, or direct thiobenzoylation of 4 gave the 3,4-diaza-1,6aλ4-trithiapentalenes 9.