5544-04-7

Usage

Classification

Selective 5-lipoxygenase inhibitor
Inhibits the production of leukotrienes, which play a role in inflammation and immune response

Medical use

Treatment of asthma
Reduces inflammation in the airways
Prevents bronchoconstriction

Physical form

White crystalline powder

Molecular weight

220.29 g/mol

Administration

Oral (tablet form)

Metabolism

In the liver

Importance

Therapeutic agent for managing asthma and related conditions

Upstream product

• 98322-24-8 C₉H₇N₂OS^(1-)*Na⁽¹⁺⁾ 
• 74-88-4 methyl iodide 
• 98322-26-0 Potassium salt of 1-methyl-2-thioxo-4-quinazolone 

Downstream Products

• 109792-00-9 1-methyl-2-<3-<3-(1-piperidinylmethyl)phenoxy>propylamino>-4(1H)-quinazolinone 

Relevant academic research and scientific papers

SYNTHESIS AND SPECTRAL EXAMINATION OF THE POSITION OF TAUTOMERIC EQUILIBRIUM IN 2-THIOXO-4-QUINAZOLONE

2-Thioxo-4-quinazolone and its derivatives mono- and dimethylated at ring atoms N(1) and N(3) and the exocyclic sulfur have been synthesized.Using model compounds, UV spectroscopy has been used to show that 2-thioxo-4-quinazolone exists in the thioketo-form, no appreciable amounts of the thiol or enol isomers being present.

ALKYLATION OF THE SALTS OF 1-METHYL-2-THIOXOQUINAZOLIN-4-ONES

During the alkylation of 1-methyl-2-thioxoquinozolin-4-one the methyl group adds mainly at the N3 atom.In the case of the "hard" alkylating agent methyl p-toluenesulfonate the reaction hardly depends at all on the nature of the counterion and the solvent.