554407-02-2

Upstream product

• 5804-73-9 5-acetamido-2-methoxybenzene-1-sulfonyl chloride 
• 51-66-1 4-methoxyacetanilide 
• 104-94-9 4-methoxy-aniline 

Relevant academic research and scientific papers

BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF

The present disclosure provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled compounds, and prodrugs thereof. The provided compounds may be tumor necrosis factor ("TNF") receptor associated protein 1 ("TRAP1") modulators (e.g., TRAP1 activators). The provided compounds may also rescue the activity in PTEN-induced kinase 1 ("PINK1") loss of function contexts. The provided compounds may also improve mitochondrial health, function, quality, quantity, and/or activity, and/or reduce the production of reactive oxygen species. The provided compounds may also refold or solubilize aggregated or misfolded proteins such as α-synuclein. The present disclosure also provides pharmaceutical compositions comprising the provided compounds; kits comprising the provided compounds or pharmaceutical compositions; and methods of using the provided compounds and pharmaceutical compositions (e.g., for treating a disease in a subject in need thereof).

Synthesis of new dihydropyrrol-2-one derivatives bearing sulfonamide groups and studies their antibacterial activity

Abstract: A novel series of dihydropyrrol-2-one compounds bearing sulfonamide groups were synthesized and assayed for in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Streptococcus epidermidis bacteria. Antibacterial results showed that most of the compounds exhibited the antibacterial activity against P. aeruginosa and S. epidermidis and displayed no inhibition against S. aureus and E. coli. Interestingly, most of the screened compounds were more active than the reference drug trimethoprim-sulfamethoxazole against P. aeruginosa. Among them, one compound exhibited good antibacterial activity in comparison with the reference drugs against P. aeruginosa and may make it as potential an antibacterial agent. Graphical abstract: [Figure not available: see fulltext.].