554430-53-4Relevant academic research and scientific papers
Identification and structure - Activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms
Jain, Nareshkumar,Xu, Jiayi,Kanojia, Ramesh M.,Du, Fuyong,Guo, Jian-Zhong,Pacia, Emmanuel,Lai, Muh-Tsann,Musto, Amy,Allan, George,Reuman, Michael,Li, Xun,Hahn, DoWon,Cousineau, Martin,Peng, Sean,Ritchie, David,Russell, Ronald,Lundeen, Scott,Sui, Zhihua
scheme or table, p. 7544 - 7569 (2010/06/13)
As part of a program aimed at the development of selective estrogen receptor modulators (SERMs), novel chromene scaffolds, benzopyranobenzoxapanes, were discovered. Many compounds showed binding affinity as low as 1.6-200 nM, displayed antagonist behavior
