Cas 554430-64-7,3-(2,4-dihydroxy-phenyl)-4-(2-hydroxy-ethyl)-6-methyl-chromen-2-one

554430-64-7

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Basic information

Product Name: 3-(2,4-dihydroxy-phenyl)-4-(2-hydroxy-ethyl)-6-methyl-chromen-2-one
Synonyms: 3-(2,4-dihydroxy-phenyl)-4-(2-hydroxy-ethyl)-6-methyl-chromen-2-one
CAS NO:554430-64-7
Molecular Formula:
Molecular Weight: 312.322
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 3-(2,4-dihydroxy-phenyl)-4-(2-hydroxy-ethyl)-6-methyl-chromen-2-one(CAS DataBase Reference)
NIST Chemistry Reference: 3-(2,4-dihydroxy-phenyl)-4-(2-hydroxy-ethyl)-6-methyl-chromen-2-one(554430-64-7)
EPA Substance Registry System: 3-(2,4-dihydroxy-phenyl)-4-(2-hydroxy-ethyl)-6-methyl-chromen-2-one(554430-64-7)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 554430-64-7(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 554430-64-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,5,4,4,3 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 554430-64:
(8*5)+(7*5)+(6*4)+(5*4)+(4*3)+(3*0)+(2*6)+(1*4)=147
147 % 10 = 7
So 554430-64-7 is a valid CAS Registry Number.

554430-64-7Upstream product

1207946-93-7 C₂₁H₂₂O₅

554430-64-7Downstream Products

554430-64-7Relevant academic research and scientific papers

Identification and structure - Activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms

Jain, Nareshkumar,Xu, Jiayi,Kanojia, Ramesh M.,Du, Fuyong,Guo, Jian-Zhong,Pacia, Emmanuel,Lai, Muh-Tsann,Musto, Amy,Allan, George,Reuman, Michael,Li, Xun,Hahn, DoWon,Cousineau, Martin,Peng, Sean,Ritchie, David,Russell, Ronald,Lundeen, Scott,Sui, Zhihua

scheme or table, p. 7544 - 7569 (2010/06/13)

As part of a program aimed at the development of selective estrogen receptor modulators (SERMs), novel chromene scaffolds, benzopyranobenzoxapanes, were discovered. Many compounds showed binding affinity as low as 1.6-200 nM, displayed antagonist behavior

Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators

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Page/Page column 85, (2010/01/31)

The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.

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