554431-76-4Relevant academic research and scientific papers
Synthesis of tetracyclic heterocompounds as selective estrogen receptor modulators. Part 3. Development of an acid-catalyzed racemization process for (s)-2,8-(dimethoxy)-5-{4-[2-(1-piperidinyl)ethoxy]-phenyl}-11,12-dihydro-5H-6, 13-dioxabenzo[3,4]cyclohep
Li, Xun,Russell, Ronald K.,Horvath, Andras,Jain, Nareshkumar,Depre, Dominique,Ormerod, Dominic,Aelterman, Wim,Sui, Zhihua
, p. 102 - 105 (2009)
A novel and economical process was developed for recycling the undesired enantiomer, (S)-2,8-dimethoxy-5-{4-[2-(1-piperidinyl)-ethoxy]phenyl}-11,12- dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-α]naphthalene (1b) obtained from chiral chromatographic sepa
Identification and structure - Activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms
Jain, Nareshkumar,Xu, Jiayi,Kanojia, Ramesh M.,Du, Fuyong,Guo, Jian-Zhong,Pacia, Emmanuel,Lai, Muh-Tsann,Musto, Amy,Allan, George,Reuman, Michael,Li, Xun,Hahn, DoWon,Cousineau, Martin,Peng, Sean,Ritchie, David,Russell, Ronald,Lundeen, Scott,Sui, Zhihua
supporting information; experimental part, p. 7544 - 7569 (2010/06/13)
As part of a program aimed at the development of selective estrogen receptor modulators (SERMs), novel chromene scaffolds, benzopyranobenzoxapanes, were discovered. Many compounds showed binding affinity as low as 1.6-200 nM, displayed antagonist behavior
