554453-84-8

Upstream product

• 554453-81-5 5-(4-hydroxy-phenyl)-1-methyl-1H-pyrimidin-2-one 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 182281-01-2 4-(tetrahydro-2H-pyran-2-yloxy)phenylboronic acid 
• 1610962-99-6 C₁₅H₁₅ClN₂O₂ 

Downstream Products

• 374633-82-6 4-[2-[1-(2,3-dihydrobenzofuran-5-yl)-1,3,4,9-tetrahydro-β-carbolin-2-yl]-pyrimidin-5-yl]-phenol 
• 1610962-92-9 C₃₄H₆₂N₂O₂Si₃ 
• 1610962-93-0 C₃₅H₆₄N₂O₂Si₃ 
• 1610962-94-1 C₃₆H₆₆N₂O₂Si₃ 
• 1610962-95-2 C₃₇H₆₈N₂O₂Si₃ 
• 1610962-96-3 C₃₈H₇₀N₂O₂Si₃ 
• 1610962-97-4 C₃₉H₇₂N₂O₂Si₃ 
• 1610963-01-3 C₁₄H₁₅ClN₂O 
• 1610963-02-4 C₁₅H₁₇ClN₂O 
• 1610963-03-5 C₁₆H₁₉ClN₂O 
• 194481-59-9 C₁₇H₂₁ClN₂O 
• 1610963-04-6 C₁₈H₂₃ClN₂O 
• 1610963-05-7 C₁₉H₂₅ClN₂O 

Relevant academic research and scientific papers

Design of liquid crystals with 'de Vries-like' properties: Carbosilane-terminated 5-phenylpyrimidine mesogens suitable for chevron-free FLC formulations

Smectic liquid crystals with 'de Vries-like' properties are characterized by a maximum layer contraction of ≤1% upon transition from the orthogonal SmA phase to the tilted SmC phase. In an effort to expand the library of 'de Vries-like' liquid crystals required for the formulation of chevron-free ferroelectric liquid crystal mixtures, we report the synthesis of a homologous series of tricarbosilane 5-phenylpyrimidine liquid crystals QL16-n using an improved synthetic route, and the characterization of their liquid crystalline and 'de Vries-like' properties. Measurements of orientational order parameters S2 and effective molecular lengths Leff by monodomain 2D X-ray scattering suggest that 'de Vries-like' behavior in series QL16-n is due to the combined effect of an increase in S2 and a decrease in bilayer interdigitation, thus causing a smectic layer expansion that compensates for the molecular tilt in the SmC phase. We also show how the optical tilt angle in the SmC phase may be optimized for SSFLC displays - without compromising 'de Vries-like' properties - by shortening the tricarbosilane end-group to a dicarbosilane. Two of the new materials reported herein, 5-[4-(12,12,14,14,16, 16-hexamethyl-12,14,16-trisilaheptadecyloxy)phenyl]-2-hexyloxypyrimidine (QL16-6) and 2-hexyloxy-5-[4-(12,12,14,14-tetramethyl-12,14-disilapentadecyloxy) phenyl]pyrimidine (QL24-6) rank among the best 'de Vries-like' materials reported heretofore, with broad SmC phases and reduction factors R of 0.17 and 0.18, respectively, at a reduced temperature T - TAC = -10 K. We also show that inverting the orientation of the 5-phenylpyrimidine core in the homologous series QL17-n causes a suppression of 'de Vries-like' properties. These results suggest that non-covalent core-core interactions in the intercalated smectic bilayers formed by these mesogens may influence 'de Vries-like' behavior.

Simple microwave-assisted ligand-free Suzuki cross-coupling: Functionalization of halo-pyrimidine moieties

(Chemical Equation Presented) An advantageous ligand-free protocol for Suzuki couplings is described. The synthetic procedure entails microwave irradiation for the reduction of the reaction times and the use of silica cartridges for the purification. Dihalo-pyrimidine structures, interesting scaffolds in medicinal chemistry, were chosen as test compounds.

Synthesis and biological activities of novel β-carbolines as PDE5 inhibitors

A series of N2-furoyl and N2pyrimidinyl β-carbolines was discovered to possess potent inhibitory activity against PDE5. During the synthesis we developed a tandem resin quenching protocol, which allowed us to synthesize large number