55453-89-9

Basic information

• Product Name: BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY]
• Synonyms: 4-[(2-carboxyphenyl)Methoxy]benzeneacetic acid;2-((4-(Carboxymethyl);BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY];2-[(4-Carboxymethylphenoxy)methyl]benzoic acid
• CAS NO: 55453-89-9
• Molecular Formula: C₁₆H₁₄O₅
• Molecular Weight: 286.28
• EINECS: 1308068-626-2
• Mol File: 55453-89-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 181-183 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 516.6 °C at 760 mmHg
• Flash Point: 194.7 °C
• Appearance: /
• Density: 1.337g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.82±0.36(Predicted)
• CAS DataBase Reference: BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY](CAS DataBase Reference)
• NIST Chemistry Reference: BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY](55453-89-9)
• EPA Substance Registry System: BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY](55453-89-9)

Safety Data

• Hazardous Substances Data: 55453-89-9(Hazardous Substances Data)

Usage

General Description

Benzene acetic acid, 4-[(2-carboxyphenyl)methoxy] is a chemical compound with the molecular formula C16H14O5. It is also known by its trade name, Diclofenac. This chemical has analgesic and anti-inflammatory properties and is commonly used as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain, inflammation, and other symptoms of arthritis, gout, and migraine. It works by inhibiting the production of prostaglandins, which are responsible for causing pain and inflammation in the body. BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY] is available in various forms, including oral tablets, eye drops, and topical gels, and is commonly prescribed by healthcare professionals to patients experiencing pain and inflammation.

InChI:InChI=1S/C16H14O5/c17-15(18)9-11-5-7-13(8-6-11)21-10-12-3-1-2-4-14(12)16(19)20/h1-8H,9-10H2,(H,17,18)(H,19,20)

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 156-38-7 4-hydroxyphenylacetate 
• 34040-62-5 o-(chloromethyl)benzoic acid methyl ester 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 1009378-92-0 4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 
• 2417-73-4 methyl 2-bromomethylbenzoate 

Downstream Products

• 113806-05-6 olopatadine 
• 113806-06-7 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid 
• 140462-76-6 olopatadine hydrochloride 
• 173677-68-4 N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)-1,1-(dimethylethyl)carbamate 
• 173677-70-8 N-<2-(6,11-dihydro-11-oxodibenzoxepin-2-yl)ethyl>-N-(phenylmethoxy)acetamide 
• 55453-87-7 isoxepac 

Relevant articles and documents

Preparation method of olopatadine hydrochloride

The method comprises the following steps: [3 - (dimethylamino) propyl] triphenylphosphonium bromide hydrobromide is added into tetrahydrofuran. The sodium hydride and dimethyl sulfoxide are added 11 - oxo -6, 11 - dihydrodibenzo [b, e] oxazepine -2 - acetic acid and stirred until the reaction system forms a black brown suspension reaction. The reaction solution is quenched by a mixed solution of purified water and tetrahydrofuran, and then the aqueous phase is treated with a mixed solvent of hydrochloric acid and n-butanol. The olopatadine hydrochloride is stirred and added with hydrochloric acid to form a white turbid liquid, and then is filtered through stirring after stirring, and is dried to obtain olopatadine hydrochloride, and the prepared oxalolopatadine hydrochloride is high in yield and short in reaction route.

IMPROVED PROCESS FOR LL-[(Z)-3-(DIMETHYLAMINO)PROPYIIDENEL-6-LL- DIHYDRODIBENZ[B,EL OXEPIN-2-ACETICACID

The present invention relates to an improved process for the preparation of 11- [(Z)-3-(dimethylamino)propylidene]-6, 11 -dihydrodibenzo[b,e]oxepin-2-aceticacid compound of formula- 1 and its pharmaceutically acceptable salts.

TERTIARY ALKYL ESTER OF OXODIBENZOXEPIN ACETIC ACID

A tertiary alkyl ester represented by Formula (2): wherein R1 and R2 each independently represent a C1-4 alkyl group, and a method for producing the same.