55461-34-2Relevant academic research and scientific papers
Selective removal of the 2′- and 3′-0-acyl groups from 2′,3′,5′-tri-O-acylribonucleoside derivatives with lithium trifluoroethoxide
Nowak, Ireneusz,Jones, Carl T.,Robins, Morris J.
, p. 3077 - 3081 (2006)
Selective cleavage of O2′ and O3′ ester groups from ribonucleoside derivatives has been accomplished with Dowex 1 × 2 (CF 3CH2O-) in 2,2,2-trifluoroethanol (TFE) or lithium trifluoroethoxide/TFE. Deacylations with Li+ -OCH2CF3/TFE proceed at ambient temperature (or with mild heating) to give the 5′-O-acyl derivatives in superior yields and higher purity than prior approaches for selective O2′ and O3′ ester deprotection.
