55463-72-4Relevant academic research and scientific papers
Versatile indole synthesis by a 5-endo-dig cyclization mediated by potassium or cesium bases
Rodriguez, Alain Louis,Koradin, Christopher,Dohle, Wolfgang,Knochel, Paul
, p. 2488 - 2490 (2000)
A mild route to indoles by cyclization of 2-(1-alkynyl)anilines is offered by the use of simple bases such as KOtBu, KH, or CsOtBu and N-methylpyrrolidinone (NMP) at room temperature. The reaction has a broad scope and allows the preparation of various functionalized indoles as well as new aza-or diazaindoles in excellent yields [see, for example, Eq. (1)].
Synthesis of polyfunctional indoles and related heterocycles mediated by cesium and potassium bases
Koradin, Christopher,Dohle, Wolfgang,Rodriguez, Alain L.,Schmid, Bertram,Knochel, Paul
, p. 1571 - 1587 (2007/10/03)
A general preparation of 2-substituted indoles starting from functionalized 2-alkynylanilines has been developed. This base mediated reaction has also been used to synthesize the heterocyclic core of the marine alkaloid hinckdentine A. Furthermore the reaction was successfully adapted to the solid phase. Benzofurans and isoindolones could also be prepared with this method.
