55464-53-4Relevant academic research and scientific papers
Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases
Cao, Shugeng,Murphy, Brian T.,Foster, Caleb,Lazo, John S.,Kingston, David G.I.
supporting information; experimental part, p. 2276 - 2281 (2009/08/15)
Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular are enzymes overexpressed in human cancer cells, and they
Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity
Brun, Marie-Priscille,Braud, Emmanuelle,Angotti, Delphine,Mondesert, Odile,Quaranta, Muriel,Montes, Matthieu,Miteva, Maria,Gresh, Nohad,Ducommun, Bernard,Garbay, Christiane
, p. 4871 - 4879 (2007/10/03)
CDC25 dual-specificity phosphatases are essential key regulators of eukaryotic cell cycle progression and the CDC25A and B isoforms are over-expressed in different tumors and related cancer cell lines. CDC25s are now considered to be interesting targets in the search for novel anticancer agents. We describe new compounds derived from vitamin K3 that inhibit CDC25B activity with IC50 values in the low micromolar range. These naphthoquinone derivatives also display antiproliferative activity on HeLa cells as expected for CDC25 inhibitors and inhibit cell growth in a clonogenic assay at submicromolar concentrations. They increase inhibitory tyrosine 15 phosphorylation of CDK and induce the cleavage of PARP, a hallmark of apoptosis.
Synthesis and spectral properties of porphyrinquinone derivatives based on deuteroporphyrin IX
Borovkov,Filippovich,Evstigneeva
, p. 494 - 501 (2007/10/02)
A series of diquinone derivatives of deuteroporphyrin IX, having different bond lengths between the chromophores, have been prepared. Deuteroporphyrin IX was condensed with modified hydroxyl-containing quinones by the mixed anhydride method. PMR spectrosc
